SCOP 1.63: Superfamily a.64.1: Saposin

Lineage for Superfamily a.64.1: Saposin

1. Root: SCOP 1.63

2. Class a: All alpha proteins [46456] (171 folds)

3. Fold a.64: Saposin-like [47861] (2 superfamilies)
   5 helices; folded leaf, closed

4. Superfamily a.64.1: Saposin [47862] (3 families)
   Lipid-binding can promote conformational changes and oligomerisation in some members

Families:

1. a.64.1.1: NKL-like [47863] (2 proteins)

2. a.64.1.2: Swaposin [47866] (1 protein)
   circularly permuted saposin domain inserted in plant acid proteases

3. a.64.1.3: Saposin B [81806] (1 protein)
   the alternative subunit conformation is an open four-helical bundle; helices 3 and 4 form a contiguous helix

More info for Superfamily a.64.1: Saposin

Timeline for Superfamily a.64.1: Saposin:

• Superfamily a.64.1: Saposin first appeared (with stable ids) in SCOP 1.55
  
• Superfamily a.64.1: Saposin appears in SCOP 1.61
  
• Superfamily a.64.1: Saposin appears in SCOP 1.65
  
• Superfamily a.64.1: Saposin appears in the current release, SCOPe 2.08