Lineage for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2321892Fold a.45: GST C-terminal domain-like [47615] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
  4. 2321893Superfamily a.45.1: GST C-terminal domain-like [47616] (3 families) (S)
    this domains follows the thioredoxin-like N-terminal domain
  5. 2321894Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain [47617] (19 protein domains)

Protein Domains:

  1. 2321895Chloride intracellular channel 1 (clic1) [69033] (1 species)
    similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition
  2. 2321907Class alpha GST [81349] (8 species)
    1. 2321908Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89060] (4 PDB entries)
    2. 2321916Species Fasciola hepatica [TaxId:6192] [47634] (2 PDB entries)
    3. 2321920Species Human (Homo sapiens), (a1-1) [TaxId:9606] [47625] (30 PDB entries)
      Uniprot P08263
    4. 2322020Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [47627] (2 PDB entries)
    5. 2322025Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [47628] (2 PDB entries)
    6. 2322030Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89059] (1 PDB entry)
    7. 2322033Species Norway rat (Rattus norvegicus), (a1-1) [TaxId:10116] [47626] (2 PDB entries)
    8. 2322040Species Schistosoma japonicum [TaxId:6182] [47633] (14 PDB entries)
      Uniprot P08515
  3. 2322060Class beta GST [81357] (4 species)
    1. 2322061Species Escherichia coli [TaxId:562] [47638] (3 PDB entries)
    2. 2322067Species Ochrobactrum anthropi [TaxId:529] [225312] (2 PDB entries)
    3. 2322070Species Proteus mirabilis [TaxId:584] [47639] (2 PDB entries)
    4. 2322076Species Sphingomonas paucimobilis [TaxId:13689] [47640] (1 PDB entry)
  4. 2322081Class delta GST [81355] (6 species)
    formerly a part of class theta enzymes
    1. 2322082Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [101209] (1 PDB entry)
    2. 2322085Species Anopheles dirus [TaxId:7168] [224848] (2 PDB entries)
    3. 2322090Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [74724] (1 PDB entry)
    4. 2322097Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [74725] (1 PDB entry)
    5. 2322100Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [101207] (1 PDB entry)
    6. 2322102Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [101208] (1 PDB entry)
  5. 2322107Class mu GST [81348] (3 species)
    1. 2322108Species Chicken (Gallus gallus) [TaxId:9031] [47624] (2 PDB entries)
    2. 2322115Species Human (Homo sapiens) [TaxId:9606] [47622] (16 PDB entries)
      Uniprot P09488 P28161
    3. 2322171Species Norway rat (Rattus norvegicus) [TaxId:10116] [47623] (16 PDB entries)
  6. 2322207Class omega GST [81352] (1 species)
  7. 2322224Class phi GST [81356] (3 species)
    1. 2322225Species Maize (Zea mays), type I [TaxId:4577] [47636] (2 PDB entries)
    2. 2322232Species Maize (Zea mays), type III [TaxId:4577] [47637] (1 PDB entry)
    3. 2322234Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [47635] (2 PDB entries)
  8. 2322238Class pi GST [81347] (4 species)
    1. 2322239Species Human (Homo sapiens) [TaxId:9606] [47619] (64 PDB entries)
    2. 2322380Species Mouse (Mus musculus) [TaxId:10090] [47621] (10 PDB entries)
    3. 2322405Species Onchocerca volvulus [TaxId:6282] [116911] (2 PDB entries)
      Uniprot P46427
    4. 2322412Species Pig (Sus scrofa) [TaxId:9823] [47620] (1 PDB entry)
  9. 2322415Class sigma GST [81351] (5 species)
    1. 2322416Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [81771] (1 PDB entry)
    2. 2322419Species Heligmosomoides polygyrus [TaxId:6339] [109834] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment
    3. 2322428Species Human (Homo sapiens) [TaxId:9606] [89061] (8 PDB entries)
      Uniprot O60760; synonym: hematopoietic prostaglandin D synthase
    4. 2322455Species Norway rat (Rattus norvegicus) [TaxId:10116] [47630] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase
    5. 2322458Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [47631] (2 PDB entries)
  10. 2322461Class tau GST [81354] (2 species)
    1. 2322462Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [74726] (1 PDB entry)
    2. 2322466Species Rice (Oryza sativa) [TaxId:4530] [89062] (1 PDB entry)
  11. 2322471Class theta GST [81350] (1 species)
  12. 2322479Class zeta GST [81353] (2 species)
    1. 2322480Species Human (Homo sapiens) [TaxId:9606] [63555] (1 PDB entry)
      maleylacetoacetate isomerase
    2. 2322482Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [63556] (1 PDB entry)
  13. 2322484Glutaredoxin 2 [63557] (1 species)
    similar to class zeta enzymes
  14. 2322487GST-like domain of elongation factor 1-gamma [81772] (1 species)
  15. 2322490Hypothetical protein AGR_pAT_752p/Atu5508 [140558] (1 species)
    putative glutathione S-transferase
  16. 2322496Microsomal prostaglandin E synthase-2 [140556] (1 species)
  17. 2322506Pf GST [101210] (1 species)
    cannot be assigned to any of the known GST classes
  18. 2322520Yeast prion protein ure2p, nitrogen regulation fragment [47641] (1 species)
    similar to class phi enzymes
  19. 2322548automated matches [226848] (11 species)
    not a true protein
    1. 2322549Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [225081] (4 PDB entries)
    2. 2322557Species Blood fluke (Schistosoma mansoni) [TaxId:6183] [224992] (1 PDB entry)
    3. 2322559Species Escherichia coli [TaxId:83333] [256898] (2 PDB entries)
    4. 2322562Species Human (Homo sapiens) [TaxId:9606] [224956] (38 PDB entries)
    5. 2322684Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [225818] (3 PDB entries)
    6. 2322691Species Mouse (Mus musculus) [TaxId:10090] [225047] (2 PDB entries)
    7. 2322695Species Salmonella enterica [TaxId:99287] [225743] (1 PDB entry)
    8. 2322697Species Schistosoma japonicum [TaxId:6182] [225615] (2 PDB entries)
    9. 2322701Species Shigella flexneri [TaxId:198215] [226693] (1 PDB entry)
    10. 2322706Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [318877] (4 PDB entries)
    11. 2322749Species Wuchereria bancrofti [TaxId:6293] [226430] (1 PDB entry)

More info for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

Timeline for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain: