SCOPe 2.08: Domain d7ki9a1: 7ki9 A:1-165

Lineage for d7ki9a1 (7ki9 A:1-165)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein automated matches [190514] (12 species)
   not a true protein

7. Species Mycobacterium ulcerans [TaxId:362242] [395872] (10 PDB entries)

8. Domain d7ki9a1: 7ki9 A:1-165 [418231]
   Other proteins in same PDB: d7ki9a2
   automated match to d6uwqa_
   complexed with nap, wfj

Details for d7ki9a1

PDB Entry: 7ki9, 1.25 Å

PDB Description: crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001912

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d7ki9a1:

Sequence, based on SEQRES records:

>d7ki9a1 c.71.1.1 (A:1-165) automated matches {Mycobacterium ulcerans [TaxId: 362242]}
mtsvgliwaqstsgvigrdggipwrlpedlahfkrltmghtvvmgrrtwdslpaahrplp
grrnvvvtrqtglvahgaqvvgsleqalspaepdaatwviggaqiyalalplanrcevte
vdvdlppededalapvldqtwagtsgewlvsrsglryrmhsyrrl

Sequence, based on observed residues (ATOM records):

>d7ki9a1 c.71.1.1 (A:1-165) automated matches {Mycobacterium ulcerans [TaxId: 362242]}
mtsvgliwaqstsgvigrdggipwrlpedlahfkrltmghtvvmgrrtwdslpaahrplp
grrnvvvtrqtglvahgaqvvgsleqalspaatwviggaqiyalalplanrcevtevdvd
lppededalapvldqtwagtsgewlvsrsglryrmhsyrrl

Timeline for d7ki9a1:

• d7ki9a1 is new in SCOPe 2.08-stable