SCOPe 2.02: Domain d1hd7a_: 1hd7 A:

Lineage for d1hd7a_ (1hd7 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.151: DNase I-like [56218] (1 superfamily)
   contains beta-sandwich; duplication of alpha+beta motif

4. Superfamily d.151.1: DNase I-like [56219] (4 families)

5. Family d.151.1.1: DNase I-like [56220] (7 proteins)

6. Protein DNA repair endonuclease Hap1 [56223] (1 species)
   Major apurinic/apyrimidinic endonuclease APE1

7. Species Human (Homo sapiens) [TaxId:9606] [56224] (7 PDB entries)

8. Domain d1hd7a_: 1hd7 A: [41780]
   complexed with pb

Details for d1hd7a_

PDB Entry: 1hd7, 1.95 Å

PDB Description: a second divalent metal ion in the active site of a new crystal form of human apurinic/apyridinimic endonuclease, ape1, and its implications for the catalytic mechanism

PDB Compounds: (A:) DNA-(apurinic or apyrimidinic site) lyase

SCOPe Domain Sequences for d1hd7a_:

Sequence, based on SEQRES records:

>d1hd7a_ d.151.1.1 (A:) DNA repair endonuclease Hap1 {Human (Homo sapiens) [TaxId: 9606]}
lyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsenk
lpaelqelpglshqywsapsdkegysgvgllsrqcplkvsygigdeehdqegrvivaefd
sfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnp
kgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrld
yfllshsllpalcdskirskalgsdhcpitlylal

Sequence, based on observed residues (ATOM records):

>d1hd7a_ d.151.1.1 (A:) DNA repair endonuclease Hap1 {Human (Homo sapiens) [TaxId: 9606]}
lyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsegl
shqywsapysgvgllsrqcplkvsygigdeehdqegrvivaefdsfvlvtayvpnagrgl
vrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkgnkknagftpqerqg
fgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyfllshsllpalcdsk
irskalgsdhcpitlylal

Timeline for d1hd7a_:

• d1hd7a_ first appeared (with stable ids) in SCOP 1.55
  
• d1hd7a_ appears in SCOPe 2.01
  
• d1hd7a_ appears in SCOPe 2.03
  
• d1hd7a_ appears in the current release, SCOPe 2.08