SCOPe 2.03: Domain d1e7ua4: 1e7u A:726-1094

Lineage for d1e7ua4 (1e7u A:726-1094)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [56173] (5 PDB entries)

8. Domain d1e7ua4: 1e7u A:726-1094 [41710]
   Other proteins in same PDB: d1e7ua1, d1e7ua2, d1e7ua3
   complexed with kwt

Details for d1e7ua4

PDB Entry: 1e7u, 2 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOPe Domain Sequences for d1e7ua4:

Sequence, based on SEQRES records:

>d1e7ua4 d.144.1.4 (A:726-1094) Phoshoinositide 3-kinase (PI3K), catalytic domain {Pig (Sus scrofa) [TaxId: 9823]}
tamlhdftqqvqvidmlqkvtidikslsaekydvssqvisqlkqklenlqnlnlpqsfrv
pydpglkagalviekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlshwlkekcpieekfqaaverfvyscagycvatfvlgigdrhndnimisetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktslhfqkfqdvcvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkseedakkyfldqievcrdkgwtvqfn
wflhlvlgi

Sequence, based on observed residues (ATOM records):

>d1e7ua4 d.144.1.4 (A:726-1094) Phoshoinositide 3-kinase (PI3K), catalytic domain {Pig (Sus scrofa) [TaxId: 9823]}
tamlhdftqqvqvidmlqkvtidikslsaekydvssqvisqlkqklenlqnlnlpqsfrv
pydpglkagalviekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlshwlkekcpieekfqaaverfvyscagycvatfvlgigdrhndnimisetgnlfhidf
ghinkervpfvltpdflfvmgtsgkktslhfqkfqdvcvkaylalrhhtnlliilfsmml
mtgmpqltskedieyirdaltvgkseedakkyfldqievcrdkgwtvqfnwflhlvlgi

Timeline for d1e7ua4:

• d1e7ua4 first appeared (with stable ids) in SCOP 1.55
  
• d1e7ua4 appears in SCOPe 2.02
  
• d1e7ua4 appears in SCOPe 2.04
  
• d1e7ua4 appears in the current release, SCOPe 2.08