SCOPe 2.08: Domain d5lssa_: 5lss A:

Lineage for d5lssa_ (5lss A:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (3 families)

5. Family f.54.1.2: Amino acid antiporter-like [418818] (5 proteins)
   Pfam PF00324 and Pfam PF13520

6. Protein Protein lysine methyltransferase (PKMT) SET domain-containing protein 2 (SETD2) [419136] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419658] (10 PDB entries)

8. Domain d5lssa_: 5lss A: [415035]
   automated match to d4h12a_
   complexed with 76h, scn, zn

Details for d5lssa_

PDB Entry: 5lss, 1.79 Å

PDB Description: structure of the epigenetic oncogene mmset and inhibition by n-alkyl sinefungin derivatives

PDB Compounds: (A:) Histone-lysine N-methyltransferase SETD2

SCOPe Domain Sequences for d5lssa_:

Sequence, based on SEQRES records:

>d5lssa_ f.54.1.2 (A:) Protein lysine methyltransferase (PKMT) SET domain-containing protein 2 (SETD2) {Human (Homo sapiens) [TaxId: 9606]}
lvgpscvmddfrdpqrwkecakqgkmpcyfdlieenvylterkknkshrdikrmqcectp
lskderaqgeiacgedclnrllmiecssrcpngdycsnrrfqrkqhadveviltekkgwg
lraakdlpsntfvleycgevldhkefkarvkeyarnknihyyfmalkndeiidatqkgnc
srfmnhscepncetqkwtvngqlrvgffttklvpsgseltfdyqfqrygkeaqkcfcgsa
ncrgylg

Sequence, based on observed residues (ATOM records):

>d5lssa_ f.54.1.2 (A:) Protein lysine methyltransferase (PKMT) SET domain-containing protein 2 (SETD2) {Human (Homo sapiens) [TaxId: 9606]}
lvgpscvmddfrdpqrwkecakqgkmpcyfdlieenvylterkmqcectplskderaqge
iacgedclnrllmiecssrcpngdycsnrrfqrkqhadveviltekkgwglraakdlpsn
tfvleycgevldhkefkarvkeyarnknihyyfmalkndeiidatqkgncsrfmnhscep
ncetqkwtvngqlrvgffttklvpsgseltfdyqfqrygkeaqkcfcgsancrgylg

Timeline for d5lssa_:

• d5lssa_ is new in SCOPe 2.08-stable