SCOP 1.71: Domain d2abl_2: 2abl 140-237

Lineage for d2abl_2 (2abl 140-237)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (1 family)

5. Family d.93.1.1: SH2 domain [55551] (31 proteins)
   Pfam 00017

6. Protein Abl tyrosine kinase [55581] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55582] (1 PDB entry)

8. Domain d2abl_2: 2abl 140-237 [40525]
   Other proteins in same PDB: d2abl_1
   mutant

Details for d2abl_2

PDB Entry: 2abl, 2.5 Å

PDB Description: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

SCOP Domain Sequences for d2abl_2:

Sequence; same for both SEQRES and ATOM records:

>d2abl_2 d.93.1.1 (140-237) Abl tyrosine kinase {Human (Homo sapiens)}
slekhswyhgpvsrnaaeyllssgingsflvresesspgqrsislryegrvyhyrintas
dgklyvssesrfntlaelvhhhstvadglittlhypap

Timeline for d2abl_2:

• d2abl_2 first appeared (with stable ids) in SCOP 1.55
  
• d2abl_2 appears in SCOP 1.69
  
• d2abl_2 is called d2abla2 in SCOP 1.73
  
• d2abl_2 appears in the current release, SCOPe 2.08, called d2abla2