Lineage for Family d.93.1.1: SH2 domain

  1. Root: SCOP 1.71
  2. 595667Class d: Alpha and beta proteins (a+b) [53931] (286 folds)
  3. 608035Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
  4. 608036Superfamily d.93.1: SH2 domain [55550] (1 family) (S)
  5. 608037Family d.93.1.1: SH2 domain [55551] (31 proteins)
    Pfam 00017

Proteins:

  1. 608038Abl tyrosine kinase [55581] (2 species)
    1. 608039Species Human (Homo sapiens) [TaxId:9606] [55582] (1 PDB entry)
    2. 608041Species Mouse (Mus musculus) [TaxId:10090] [89998] (2 PDB entries)
  2. 608045Adaptor protein Aps [103139] (1 species)
  3. 608051Beta-chimaerin, N-terminal domain [118052] (1 species)
    includes N-terminal tail and the linker to the next domain
  4. 608054c-src tyrosine kinase [55556] (3 species)
    1. 608055Species Chicken (Gallus gallus) [TaxId:9031] [55558] (3 PDB entries)
    2. 608059Species Human (Homo sapiens) [TaxId:9606] [55557] (40 PDB entries)
    3. 608107Species Rous sarcoma virus [TaxId:11886] [69782] (12 PDB entries)
  5. 608129Carboxyl-terminal src kinase (csk) [75498] (1 species)
  6. 608137Cbl [55587] (1 species)
  7. 608144Crk proto-oncogen [82741] (1 species)
  8. 608147Csk homologous kinase Chk [64345] (1 species)
  9. 608150Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)
  10. 608153GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)
  11. 608165Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)
  12. 608169Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)
  13. 608200Growth factor receptor-bound protein 7 [103135] (1 species)
  14. 608203Hemopoetic cell kinase Hck [55565] (1 species)
  15. 608211Itk/tsk protein tyrosine kinase [82743] (1 species)
  16. 608217P55 Blk protein tyrosine kinase [55579] (1 species)
  17. 608221p56-lck tyrosine kinase [55552] (1 species)
  18. 608236Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)
    1. 608237Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)
    2. 608245Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)
    3. 608248Species Rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)
  19. 608251Phospholipase C-gamma-1 [55577] (1 species)
  20. 608255Proto-oncogen tyrosine kinase [55573] (1 species)
  21. 608258Shc adaptor protein [55567] (1 species)
  22. 608262STAT homologue [103137] (1 species)
  23. 608266STAT-1 [55583] (1 species)
  24. 608269STAT3b [55585] (1 species)
  25. 608272Syk tyrosine kinase [55575] (1 species)
  26. 608288The Xlp protein Sap [55591] (1 species)
  27. 608300Tyrosine kinase Fyn [55559] (1 species)
  28. 608306Tyrosine phoshatase shp-2 [55589] (1 species)
  29. 608312Tyrosine phosphatase Syp [55561] (1 species)
  30. 608319Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)
  31. 608322Tyrosine-protein kinase zap-70 [89996] (1 species)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain: