SCOPe 2.08: Domain d7jwza3: 7jwz A:525-725

Lineage for d7jwza3 (7jwz A:525-725)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (28 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (77 PDB entries)

8. Domain d7jwza3: 7jwz A:525-725 [402064]
   Other proteins in same PDB: d7jwza1, d7jwza2, d7jwza4
   automated match to d1e8ya1
   complexed with v7y

Details for d7jwza3

PDB Entry: 7jwz, 2.65 Å

PDB Description: ipi-549 bound to the pi3kg catalytic subunit p110 gamma

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d7jwza3:

Sequence, based on SEQRES records:

>d7jwza3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
hpialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslk
hpkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraia
vqklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseia
qsrhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d7jwza3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
hpiaempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqq
eivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyll
qlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileayl
rgcg

Timeline for d7jwza3:

• d7jwza3 first appeared in SCOPe 2.07