SCOPe 2.07: Domain d7aema_: 7aem A:

Lineage for d7aema_ (7aem A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (129 PDB entries)
   Uniprot P00533 702-1018

8. Domain d7aema_: 7aem A: [401664]
   automated match to d4zseb_
   complexed with 6gy; mutant

Details for d7aema_

PDB Entry: 7aem, 2.65 Å

PDB Description: studies towards a reversible egfr c797s triple mutant inhibitor series

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d7aema_:

Sequence, based on SEQRES records:

>d7aema_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d7aema_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlplmdeed
mddvvdadeyli

Timeline for d7aema_:

• d7aema_ is new in SCOPe 2.07-stable
  
• d7aema_ appears in the current release, SCOPe 2.08