SCOPe 2.08: Domain d6qvlb_: 6qvl B:

Lineage for d6qvlb_ (6qvl B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.67: PLP-dependent transferase-like [53382] (3 superfamilies)
   main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest

4. Superfamily c.67.1: PLP-dependent transferases [53383] (10 families)

5. Family c.67.1.4: GABA-aminotransferase-like [53417] (17 proteins)
   formerly omega-Aminoacid:pyruvate aminotransferase-like

6. Protein Serine hydroxymethyltransferase [53429] (7 species)

7. Species Human (Homo sapiens), mitochondrial [TaxId:9606] [142671] (9 PDB entries)
   Uniprot P34897 42-504

8. Domain d6qvlb_: 6qvl B: [373772]
   automated match to d3ou5a_
   complexed with 4dw, ca, gol, peg, plp

Details for d6qvlb_

PDB Entry: 6qvl, 2.28 Å

PDB Description: human shmt2 in complex with pemetrexed

PDB Compounds: (B:) Serine hydroxymethyltransferase, mitochondrial

SCOPe Domain Sequences for d6qvlb_:

Sequence, based on SEQRES records:

>d6qvlb_ c.67.1.4 (B:) Serine hydroxymethyltransferase {Human (Homo sapiens), mitochondrial [TaxId: 9606]}
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlpdgghlthgymsdvkrisatsiffesmpyklnpktglidynqlaltarlfrprlii
agtsayarlidyarmrevcdevkahlladmahisglvaakvipspfkhadivtttthktl
rgarsglifyrkgvkavdpktgreipytfedrinfavfpslqggphnhaiaavavalkqa
ctpmfreyslqvlknaramadallergyslvsggtdnhlvlvdlrpkgldgaraervlel
vsitankntcpgdrsaitpgglrlgapaltsrqfreddfrrvvdfidegvniglevkskt
aklqdfksfllkdsetsqrlanlrqrveqfarafpmpgfdeh

Sequence, based on observed residues (ATOM records):

>d6qvlb_ c.67.1.4 (B:) Serine hydroxymethyltransferase {Human (Homo sapiens), mitochondrial [TaxId: 9606]}
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlpdgghlthgymsdvkrisatsiffesmpyklnpktglidynqlaltarlfrprlii
agtsayarlidyarmrevcdevkahlladmahisglvaakvipspfkhadivtttthktl
rgarsglifyrkgvkaipytfedrinfavfpslqggphnhaiaavavalkqactpmfrey
slqvlknaramadallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankn
tcpgdrsaitpgglrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfks
fllkdsetsqrlanlrqrveqfarafpmpgfdeh

Timeline for d6qvlb_:

• d6qvlb_ first appeared in SCOPe 2.07