SCOPe 2.08: Domain d6qu7a_: 6qu7 A:

Lineage for d6qu7a_ (6qu7 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d6qu7a_: 6qu7 A: [371458]
   automated match to d3kvma_
   complexed with act, fmn, jje, oro, so4
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d6qu7a_

PDB Entry: 6qu7, 1.52 Å

PDB Description: crystal structure of human dhodh in complex with bay 2402234

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d6qu7a_:

Sequence, based on SEQRES records:

>d6qu7a_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedias
vvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpi
igvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdai
gadhrr

Sequence, based on observed residues (ATOM records):

>d6qu7a_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllprafqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrsgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Timeline for d6qu7a_:

• d6qu7a_ first appeared in SCOPe 2.07