SCOPe 2.04: Domain d7pckb_: 7pck B:

Lineage for d7pckb_ (7pck B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein (Pro)cathepsin K [54028] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54029] (42 PDB entries)
   Uniprot P43235 116-329 ! Uniprot P43235 115-329

8. Domain d7pckb_: 7pck B: [37080]
   contains propeptide

Details for d7pckb_

PDB Entry: 7pck, 3.2 Å

PDB Description: crystal structure of wild type human procathepsin k

PDB Compounds: (B:) protein (procathepsin k)

SCOPe Domain Sequences for d7pckb_:

Sequence, based on SEQRES records:

>d7pckb_ d.3.1.1 (B:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
lypeeildthwelwkkthrkqynnkvdeisrrliweknlkyisihnleaslgvhtyelam
nhlgdmtseevvqkmtglkvplshsrsndtlyipewegrapdsvdyrkkgyvtpvknqgq
cgscwafssvgalegqlkkktgkllnlspqnlvdcvsendgcgggymtnafqyvqknrgi
dsedaypyvgqeescmynptgkaakcrgyreipegnekalkravarvgpvsvaidaslts
fqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiiknswgenwgnkgyilmarnkn
nacgianlasfpkm

Sequence, based on observed residues (ATOM records):

>d7pckb_ d.3.1.1 (B:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
lypeeildthwelwkkthrkqynnkvdeisrrliweknlkyisihnleaslgvhtyelam
nhlgdmtseevvqkmtglkvplrsndtlyipewegrapdsvdyrkkgyvtpvknqgqcgs
cwafssvgalegqlkkktgkllnlspqnlvdcvsendgcgggymtnafqyvqknrgidse
daypyvgqeescmynptgkaakcrgyreipegnekalkravarvgpvsvaidasltsfqf
yskgvyydescnsdnlnhavlavgygiqkgnkhwiiknswgenwgnkgyilmarnknnac
gianlasfpkm

Timeline for d7pckb_:

• d7pckb_ first appeared (with stable ids) in SCOP 1.55
  
• d7pckb_ appears in SCOPe 2.03
  
• d7pckb_ appears in SCOPe 2.05
  
• d7pckb_ appears in the current release, SCOPe 2.08