Lineage for d6ecqa2 (6ecq A:127-296)

  1. Root: SCOPe 2.07
  2. 2434694Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2449371Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2449372Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2453552Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  6. 2453840Protein automated matches [227005] (6 species)
    not a true protein
  7. 2453900Species Homo sapiens [TaxId:9606] [353659] (4 PDB entries)
  8. 2453902Domain d6ecqa2: 6ecq A:127-296 [366743]
    Other proteins in same PDB: d6ecqa1, d6ecqb1, d6ecqb2
    automated match to d1a4ia1
    complexed with lud, nap

Details for d6ecqa2

PDB Entry: 6ecq (more details), 2.7 Å

PDB Description: the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (fold) complexed with nadp and inhibitor ly345899
PDB Compounds: (A:) methylenetetrahydrofolate dehydrogenase cyclohydrolase

SCOPe Domain Sequences for d6ecqa2:

Sequence, based on SEQRES records: (download)

>d6ecqa2 c.2.1.7 (A:127-296) automated matches {Homo sapiens [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d6ecqa2 c.2.1.7 (A:127-296) automated matches {Homo sapiens [TaxId: 9606]}

SCOPe Domain Coordinates for d6ecqa2:

Click to download the PDB-style file with coordinates for d6ecqa2.
(The format of our PDB-style files is described here.)

Timeline for d6ecqa2:

View in 3D
Domains from same chain:
(mouse over for more information)