SCOPe 2.08: Domain d6mdcb1: 6mdc B:4-110

Lineage for d6mdcb1 (6mdc B:4-110)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.0: automated matches [191409] (1 protein)
   not a true family

6. Protein automated matches [190561] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187549] (77 PDB entries)

8. Domain d6mdcb1: 6mdc B:4-110 [364972]
   Other proteins in same PDB: d6mdca3, d6mdcb3
   automated match to d2shpa2
   complexed with jea, po4

Details for d6mdcb1

PDB Entry: 6mdc, 2.14 Å

PDB Description: non-receptor protein tyrosine phosphatase shp2 in complex with allosteric inhibitor pyrazolo-pyrimidinone 1 shp389

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d6mdcb1:

Sequence, based on SEQRES records:

>d6mdcb1 d.93.1.0 (B:4-110) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptse

Sequence, based on observed residues (ATOM records):

>d6mdcb1 d.93.1.0 (B:4-110) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymeielkyplncadptse

Timeline for d6mdcb1:

• d6mdcb1 first appeared in SCOPe 2.07