SCOPe 2.06: Domain d5kaea2: 5kae A:352-522

Lineage for d5kaea2 (5kae A:352-522)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (61 PDB entries)

8. Domain d5kaea2: 5kae A:352-522 [335596]
   Other proteins in same PDB: d5kaea1, d5kaea3, d5kaea4
   automated match to d1he8a2
   complexed with 6rf, so4

Details for d5kaea2

PDB Entry: 5kae, 2.65 Å

PDB Description: crystal structure of human pi3k-gamma in complex with quinoline- containing inhibitor 5g

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5kaea2:

Sequence, based on SEQRES records:

>d5kaea2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidh
rfllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d5kaea2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwle
fsikikdlpkgallnlqiycgkvqllyyvnlllidhrfllrrgeyvlhmwqisgsfnadk
ltsatnpdkensmsisilldn

Timeline for d5kaea2:

• d5kaea2 is new in SCOPe 2.06-stable
  
• d5kaea2 appears in SCOPe 2.07
  
• d5kaea2 appears in the current release, SCOPe 2.08