Lineage for d5l5yk_ (5l5y K:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2224590Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2224591Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2224775Family d.153.1.4: Proteasome subunits [56251] (4 proteins)
  6. 2224887Protein Proteasome alpha subunit (non-catalytic) [56255] (8 species)
    contains an extension to the common fold at the N-terminus
  7. 2224903Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (193 PDB entries)
    The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
  8. 2225936Domain d5l5yk_: 5l5y K: [325228]
    Other proteins in same PDB: d5l5ya_, d5l5yb_, d5l5yc_, d5l5yd_, d5l5ye_, d5l5yf_, d5l5yh_, d5l5yi_, d5l5yj_, d5l5ym_, d5l5yn_, d5l5yo_, d5l5yp_, d5l5yq_, d5l5yr_, d5l5ys_, d5l5yt_, d5l5yv_, d5l5yw_, d5l5yx_
    automated match to d4g4sl_
    complexed with 3bv, cl, mes, mg

Details for d5l5yk_

PDB Entry: 5l5y (more details), 2.7 Å

PDB Description: yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with carfilzomib
PDB Compounds: (K:) Proteasome subunit beta type-5,Proteasome subunit beta type-5

SCOPe Domain Sequences for d5l5yk_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5l5yk_ d.153.1.4 (K:) Proteasome alpha subunit (non-catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
tttlafkfrhgvivaadsratagayiasqtvkkvieinpyllgtmaggaadcsfwerlla
rqcriyelrnkerisvaaaskllanmvyqykgmglsmgtmicgwdkrgpglyyvdsegnr
isgatfsvgsgsvyaygvldsnykwdlsvedalylgkrsilaaahrdaysggsvnlyhvt
edgwiyhgnhdvgelfwkvkeeegsfnnvig

SCOPe Domain Coordinates for d5l5yk_:

Click to download the PDB-style file with coordinates for d5l5yk_.
(The format of our PDB-style files is described here.)

Timeline for d5l5yk_: