SCOPe 2.08: Domain d5lr6a_: 5lr6 A:

Lineage for d5lr6a_ (5lr6 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.1: COMT-like [53336] (4 proteins)

6. Protein Catechol O-methyltransferase, COMT [53337] (2 species)

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [53338] (87 PDB entries)

8. Domain d5lr6a_: 5lr6 A: [322087]
   automated match to d4pyna_
   complexed with 731, cl, nhe

Details for d5lr6a_

PDB Entry: 5lr6, 2.3 Å

PDB Description: crystal structure of comt in complex with [3-(2,4-dimethyl-1,3- thiazol-5-yl)-1h-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone

PDB Compounds: (A:) Catechol O-methyltransferase

SCOPe Domain Sequences for d5lr6a_:

Sequence, based on SEQRES records:

>d5lr6a_ c.66.1.1 (A:) Catechol O-methyltransferase, COMT {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgps

Sequence, based on observed residues (ATOM records):

>d5lr6a_ c.66.1.1 (A:) Catechol O-methyltransferase, COMT {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamvgdakgqimdavireyspslv
lelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdl
ipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflay
vrgsssfecthyssylmkvvdglekaiyqgps

Timeline for d5lr6a_:

• d5lr6a_ first appeared in SCOPe 2.06
  
• d5lr6a_ appears in SCOPe 2.07