Lineage for Protein: Catechol O-methyltransferase, COMT

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2468838Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2468839Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families) (S)
  5. 2468840Family c.66.1.1: COMT-like [53336] (4 protein domains)
  6. 2468851Protein Catechol O-methyltransferase, COMT [53337] (2 species)

Species:

  1. 2468852Human (Homo sapiens) [TaxId:9606] [267759] (10 PDB entries)
    1. Domain for 3a7e:
    2. Domain for 3bwm:
    3. Domain for 3bwy:
    4. Domain for 4pyi:
    5. Domain for 4pyj:
    6. Domain for 4pyk:
    7. Domain for 4xuc:
    8. Domain for 4xud:
    9. Domains for 4xue:
      1. 2468860Domain d4xuea_: 4xue A: [271578]
        Other proteins in same PDB: d4xueb2
        automated match to d3bwma_
        complexed with 43j, mg, sam
      2. 2468861Domain d4xueb1: 4xue B:52-265 [271577]
        Other proteins in same PDB: d4xueb2
        automated match to d3bwma_
        complexed with 43j, mg, sam
    10. Domain for 5lsa:
  2. 2468864Norway rat (Rattus norvegicus) [TaxId:10116] [53338] (85 PDB entries)
    1. Domain for 1h1d:
    2. Domain for 1jr4:
    3. Domain for 1vid:
    4. Domain for 3a7d:
    5. Domain for 3nw9:
    6. Domain for 3nwb:
      • 2468890Domain d3nwba_: 3nwb A: [196280]
        automated match to d3u81a_
        protein/RNA complex; complexed with 659, cl, mg, nhe, so4
    7. Domain for 3nwe:
      • 2468907Domain d3nwea_: 3nwe A: [196281]
        automated match to d3u81a_
        protein/RNA complex; complexed with 662, cl, mg, nhe, so4
    8. Domain for 3oe4:
    9. Domain for 3oe5:
    10. Domain for 3ozr:
    11. Domain for 3ozs:
    12. Domain for 3ozt:
    13. Domain for 3r6t:
      • 2468880Domain d3r6ta_: 3r6t A: [184825]
        automated match to d1h1da_
        protein/RNA complex; complexed with cl, dtd, lu1, mg, nhe, so4
    14. Domain for 3s68:
    15. Domain for 3u81:
    16. Domains for 4p7g:
      1. 2468976Domain d4p7ga_: 4p7g A: [257436]
        automated match to d1jr4a_
        complexed with k, po4
      2. 2468977Domain d4p7gb_: 4p7g B: [257438]
        automated match to d1h1da_
        complexed with k, po4
      3. 2468978Domain d4p7gc_: 4p7g C: [257439]
        automated match to d1h1da_
        complexed with k, po4
      4. 2468979Domain d4p7gd_: 4p7g D: [257440]
        automated match to d1h1da_
        complexed with k, po4
    17. Domain for 4p7j:
    18. Domain for 4p7k:
    19. Domain for 4pyl:
    20. Domain for 4pym:
    21. Domain for 4pyn:
    22. Domains for 4pyo:
      1. 2468933Domain d4pyoa_: 4pyo A: [259265]
        automated match to d3u81a_
        complexed with k, mg, sah
      2. 2468934Domain d4pyob_: 4pyo B: [259266]
        automated match to d3u81a_
        complexed with k, mg, sah
    23. Domains for 4pyq:
      1. 2468882Domain d4pyqa_: 4pyq A: [267248]
        automated match to d4p7ka_
        protein/RNA complex; complexed with 2x1, act, cl, na, so4
      2. 2468883Domain d4pyqb_: 4pyq B: [267249]
        automated match to d4p7ka_
        protein/RNA complex; complexed with 2x1, act, cl, na, so4
    24. Domain for 5fhq:
    25. Domains for 5fhr:
      1. 2468914Domain d5fhra_: 5fhr A: [314407]
        automated match to d2cl5a_
        complexed with br, dnc, mg, sam; mutant
      2. 2468915Domain d5fhrb_: 5fhr B: [314347]
        automated match to d2cl5a_
        complexed with br, dnc, mg, sam; mutant
    26. Domain for 5k01:
    27. Domain for 5k03:
    28. Domains for 5k05:
      1. 2468959Domain d5k05a_: 5k05 A: [322207]
        automated match to d4pyoa_
        complexed with 6p5, so4
      2. 2468960Domain d5k05b_: 5k05 B: [322430]
        automated match to d4pyoa_
        complexed with 6p5, so4
    29. Domains for 5k09:
      1. 2468984Domain d5k09a1: 5k09 A:2-217 [322231]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      2. 2468985Domain d5k09b_: 5k09 B: [322201]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      3. 2468986Domain d5k09c_: 5k09 C: [322192]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      4. 2468987Domain d5k09d_: 5k09 D: [322436]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      5. 2468988Domain d5k09e_: 5k09 E: [322432]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      6. 2468989Domain d5k09f_: 5k09 F: [322243]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      7. 2468990Domain d5k09g1: 5k09 G:2-217 [322332]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      8. 2468991Domain d5k09h_: 5k09 H: [322422]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      9. 2468992Domain d5k09i_: 5k09 I: [322412]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      10. 2468993Domain d5k09j_: 5k09 J: [322406]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      11. 2468994Domain d5k09k_: 5k09 K: [322321]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      12. 2468995Domain d5k09l_: 5k09 L: [322199]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      13. 2468996Domain d5k09m_: 5k09 M: [322206]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      14. 2468997Domain d5k09n_: 5k09 N: [322212]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      15. 2468998Domain d5k09o_: 5k09 O: [322440]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      16. 2468999Domain d5k09p_: 5k09 P: [322215]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      17. 2469000Domain d5k09q_: 5k09 Q: [322421]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      18. 2469001Domain d5k09r1: 5k09 R:2-217 [322303]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      19. 2469002Domain d5k09s_: 5k09 S: [322431]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      20. 2469003Domain d5k09t_: 5k09 T: [322399]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      21. 2469004Domain d5k09u_: 5k09 U: [322420]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      22. 2469005Domain d5k09v_: 5k09 V: [322435]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      23. 2469006Domain d5k09w_: 5k09 W: [322434]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
      24. 2469007Domain d5k09x_: 5k09 X: [322305]
        Other proteins in same PDB: d5k09a2, d5k09g2, d5k09r2
        automated match to d4pyna_
        complexed with 6pq, k, po4
    30. Domains for 5k0b:
      1. 2468968Domain d5k0ba_: 5k0b A: [322256]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      2. 2468969Domain d5k0bb_: 5k0b B: [322396]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      3. 2468970Domain d5k0bc_: 5k0b C: [322359]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      4. 2468971Domain d5k0bd1: 5k0b D:3-218 [322298]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      5. 2468972Domain d5k0be_: 5k0b E: [322247]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      6. 2468973Domain d5k0bf_: 5k0b F: [322429]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      7. 2468974Domain d5k0bg_: 5k0b G: [322214]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
      8. 2468975Domain d5k0bh_: 5k0b H: [322336]
        Other proteins in same PDB: d5k0bd2
        automated match to d3u81a_
        complexed with 6ps, cl, cxs, edo, k, po4
    31. Domains for 5k0c:
      1. 2468939Domain d5k0ca_: 5k0c A: [322423]
        automated match to d4pyob_
        complexed with 6oz, edo, na, nhe
      2. 2468940Domain d5k0cb_: 5k0c B: [322191]
        automated match to d4pyob_
        complexed with 6oz, edo, na, nhe
    32. Domain for 5k0e:
    33. Domains for 5k0f:
      1. 2468929Domain d5k0fa_: 5k0f A: [322203]
        automated match to d4pyna_
        complexed with 6p1, na, nhe
      2. 2468930Domain d5k0fb_: 5k0f B: [322367]
        automated match to d4pyna_
        complexed with 6p1, na, nhe
    34. Domains for 5k0g:
      1. 2468935Domain d5k0ga_: 5k0g A: [322224]
        automated match to d4pyna_
        complexed with 6pm, na, nhe
      2. 2468936Domain d5k0gb_: 5k0g B: [322229]
        automated match to d4pyna_
        complexed with 6pm, na, nhe
    35. Domains for 5k0j:
      1. 2468941Domain d5k0ja_: 5k0j A: [322322]
        automated match to d4pyna_
        complexed with 6p2, na, nhe
      2. 2468942Domain d5k0jb_: 5k0j B: [322353]
        automated match to d4pyna_
        complexed with 6p2, na, nhe
    36. Domains for 5k0l:
      1. 2468949Domain d5k0la_: 5k0l A: [322424]
        automated match to d4pyna_
        complexed with 6p2, k, mg, nhe
      2. 2468950Domain d5k0lb_: 5k0l B: [322426]
        automated match to d4pyna_
        complexed with 6p2, k, mg, nhe
      3. 2468951Domain d5k0lc_: 5k0l C: [322433]
        automated match to d4pyna_
        complexed with 6p2, k, mg, nhe
      4. 2468952Domain d5k0ld_: 5k0l D: [322193]
        automated match to d4pyna_
        complexed with 6p2, k, mg, nhe
    37. Domains for 5k0n:
      1. 2468944Domain d5k0na_: 5k0n A: [322244]
        automated match to d4pyna_
        complexed with 6p0, edo, k, mg, nhe
      2. 2468945Domain d5k0nb_: 5k0n B: [322223]
        automated match to d4pyna_
        complexed with 6p0, edo, k, mg, nhe
      3. 2468946Domain d5k0nc_: 5k0n C: [322234]
        automated match to d4pyna_
        complexed with 6p0, edo, k, mg, nhe
      4. 2468947Domain d5k0nd_: 5k0n D: [322235]
        automated match to d4pyna_
        complexed with 6p0, edo, k, mg, nhe
    38. Domain for 5lqa:
    39. Domain for 5lqc:
    40. Domains for 5lqj:
      1. 2468980Domain d5lqja_: 5lqj A: [323446]
        automated match to d4pyna_
        complexed with 72n, cl, k, na
      2. 2468981Domain d5lqjb_: 5lqj B: [323499]
        automated match to d4pyna_
        complexed with 72n, cl, k, na
      3. 2468982Domain d5lqjc_: 5lqj C: [323450]
        automated match to d4pyna_
        complexed with 72n, cl, k, na
      4. 2468983Domain d5lqjd_: 5lqj D: [323468]
        automated match to d4pyna_
        complexed with 72n, cl, k, na
    41. Domain for 5lqk:
    42. Domain for 5lqn:
    43. Domain for 5lqr:
    44. Domains for 5lqu:
      1. 2468927Domain d5lqua_: 5lqu A: [323766]
        automated match to d1h1da_
        complexed with 619, btb, cl, mg
      2. 2468928Domain d5lqub_: 5lqu B: [323739]
        automated match to d1h1da_
        complexed with 619, btb, cl, mg
    45. Domains for 5lr6:
      1. 2468964Domain d5lr6a_: 5lr6 A: [322087]
        automated match to d4pyna_
        complexed with 731, cl, nhe
      2. 2468965Domain d5lr6b_: 5lr6 B: [322053]
        automated match to d4pyna_
        complexed with 731, cl, nhe
      3. 2468966Domain d5lr6c_: 5lr6 C: [322012]
        automated match to d4pyna_
        complexed with 731, cl, nhe
      4. 2468967Domain d5lr6d_: 5lr6 D: [322022]
        automated match to d4pyna_
        complexed with 731, cl, nhe
    46. Domains for 5p8w:
      1. 2468953Domain d5p8wa_: 5p8w A: [322371]
        automated match to d4pyna_
        complexed with dtt, fmt, na, o01
      2. 2468954Domain d5p8wb_: 5p8w B: [322302]
        automated match to d4pyna_
        complexed with dtt, fmt, na, o01
      3. 2468955Domain d5p8wc_: 5p8w C: [322309]
        automated match to d4pyna_
        complexed with dtt, fmt, na, o01
    47. Domain for 5p8x:
    48. Domain for 5p8y:
    49. Domain for 5p8z:
    50. Domain for 5p90:
    51. Domain for 5p91:
    52. Domain for 5p92:
    53. Domain for 5p93:
    54. Domain for 5p94:
    55. Domain for 5p95:
    56. Domain for 5p96:
    57. Domain for 5p97:
    58. Domain for 5p98:
    59. Domain for 5p99:
    60. Domain for 5p9a:
    61. Domain for 5p9b:
    62. Domain for 5p9c:
    63. Domain for 5p9d:
    64. Domain for 5p9e:
    65. Domain for 5p9n:
    66. Domain for 5p9o:
    67. Domain for 5p9p:
    68. Domain for 5p9q:
    69. Domains for 5p9r:
      1. 2468921Domain d5p9ra_: 5p9r A: [341877]
        automated match to d4pyna_
        complexed with 7jj, cl, mg, na, sah
      2. 2468922Domain d5p9rb_: 5p9r B: [341878]
        automated match to d4pyna_
        complexed with 7jj, cl, mg, na, sah
    70. Domain for 5p9s:
    71. Domain for 5p9t:
    72. Domain for 5p9u:
    73. Domain for 5p9v:
    74. Domain for 5p9w:
    75. Domain for 5p9x:
    76. Domain for 5p9y:
    77. Domain for 5p9z:
    78. Domain for 5pa0:
    79. Domain for 5pa1:
    80. Domain for 5pa2:
    81. Domain for 5pa3:
    82. Domain for 5pa4:
    83. Domain for 5pa5:
    84. Domain for 5pa6:
    85. Domains for 5pa7:
      1. 2468957Domain d5pa7a_: 5pa7 A: [341896]
        automated match to d4pyna_
        complexed with 7jx, mg, na, sah
      2. 2468958Domain d5pa7b_: 5pa7 B: [341866]
        automated match to d4pyna_
        complexed with 7jx, mg, na, sah

More info for Protein Catechol O-methyltransferase, COMT from c.66.1.1: COMT-like

Timeline for Protein Catechol O-methyltransferase, COMT from c.66.1.1: COMT-like: