SCOPe 2.06: Domain d5jcxd_: 5jcx D:

Lineage for d5jcxd_ (5jcx D:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Trypanosoma brucei [TaxId:5702] [226783] (15 PDB entries)

8. Domain d5jcxd_: 5jcx D: [321430]
   automated match to d3bmob_
   complexed with act, cc6, gol, nap

Details for d5jcxd_

PDB Entry: 5jcx, 1.43 Å

PDB Description: trypanosoma brucei ptr1 in complex with inhibitor np-29

PDB Compounds: (D:) pteridine reductase

SCOPe Domain Sequences for d5jcxd_:

Sequence, based on SEQRES records:

>d5jcxd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqva
eligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhal
vgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadav
iflvsgsaqyitgsiikvdgglslvha

Sequence, based on observed residues (ATOM records):

>d5jcxd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqsnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygirv
ngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsiikv
dgglslvha

Timeline for d5jcxd_:

• d5jcxd_ is new in SCOPe 2.06-stable
  
• d5jcxd_ appears in SCOPe 2.07
  
• d5jcxd_ appears in the current release, SCOPe 2.08