SCOPe 2.08: Domain d3tmkc_: 3tmk C:

Lineage for d3tmkc_ (3tmk C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidylate kinase [52563] (5 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52564] (3 PDB entries)

8. Domain d3tmkc_: 3tmk C: [31922]
   complexed with t5a

Details for d3tmkc_

PDB Entry: 3tmk, 2 Å

PDB Description: crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor tp5a at 2.0 a resolution: implications for catalysis and azt activation

PDB Compounds: (C:) thymidylate kinase

SCOPe Domain Sequences for d3tmkc_:

Sequence, based on SEQRES records:

>d3tmkc_ c.37.1.1 (C:) Thymidylate kinase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mmgrgkliliegldrtgkttqcnilykklqpnckllkfperstrigglineyltddsfql
sdqaihllfsanrweivdkikkdllegknivmdryvysgvaysaakgtngmdldwclqpd
vgllkpdltlflstqdvdnnaeksgfgderyetvkfqekvkqtfmklldkeirkgdesit
ivdvtnkgiqevealiwqivepvlsthidhdkfsff

Sequence, based on observed residues (ATOM records):

>d3tmkc_ c.37.1.1 (C:) Thymidylate kinase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mmgrgkliliegldrtgkttqcnilykklqpnckllkfperstrigglineyltddsfql
sdqaihllfsanrweivdkikkdllegknivmdryvysgvaysaakgtngmdldwclqpd
vgllkpdltlflstqdderyetvkfqekvkqtfmklldkeirkgdesitivdvtnkgiqe
vealiwqivepvlsthidhdkfsff

Timeline for d3tmkc_:

• d3tmkc_ first appeared (with stable ids) in SCOP 1.55
  
• d3tmkc_ appears in SCOPe 2.07