SCOP 1.63: Domain d1dtwa_: 1dtw A:

Lineage for d1dtwa_ (1dtw A:)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families)
   both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
   conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules

5. Family c.36.1.3: Branched-chain alpha-keto acid dehydrogenase THDP-binding domains [52531] (3 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP and Pyr modules [52532] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52533] (1 PDB entry)

8. Domain d1dtwa_: 1dtw A: [31827]
   Other proteins in same PDB: d1dtwb2
   complexed with k, mg, tdp

Details for d1dtwa_

PDB Entry: 1dtw, 2.7 Å

PDB Description: human branched-chain alpha-keto acid dehydrogenase

SCOP Domain Sequences for d1dtwa_:

Sequence, based on SEQRES records:

>d1dtwa_ c.36.1.3 (A:) Branched-chain alpha-keto acid dehydrogenase, PP and Pyr modules {Human (Homo sapiens)}
pqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmtl
lntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdypl
elfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrv
vicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgy
gimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrsvdev
nywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsd
vyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d1dtwa_ c.36.1.3 (A:) Branched-chain alpha-keto acid dehydrogenase, PP and Pyr modules {Human (Homo sapiens)}
pqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmtl
lntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdypl
elfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrv
vicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgy
gimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrhpisr
lrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqempaqlrkq
qeslarhlqtygehypldhfdk

Timeline for d1dtwa_:

• d1dtwa_ first appeared (with stable ids) in SCOP 1.55, called d1dtwa1
  
• d1dtwa_ was called d1dtwa1 in SCOP 1.61
  
• d1dtwa_ appears in SCOP 1.65
  
• d1dtwa_ appears in the current release, SCOPe 2.08