SCOPe 2.08: Domain d1dtwa_: 1dtw A:

Lineage for d1dtwa_ (1dtw A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
   Uniprot P12694 52-445

8. Domain d1dtwa_: 1dtw A: [31827]
   Other proteins in same PDB: d1dtwb1, d1dtwb2
   complexed with k, mg, tdp

Details for d1dtwa_

PDB Entry: 1dtw, 2.7 Å

PDB Description: human branched-chain alpha-keto acid dehydrogenase

PDB Compounds: (A:) branched-chain alpha-keto acid dehydrogenase alpha subunit

SCOPe Domain Sequences for d1dtwa_:

Sequence, based on SEQRES records:

>d1dtwa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
pqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmtl
lntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdypl
elfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrv
vicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgy
gimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrsvdev
nywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsd
vyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d1dtwa_ c.36.1.11 (A:) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
pqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmtl
lntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdypl
elfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananrv
vicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpgy
gimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrhpisr
lrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqempaqlrkq
qeslarhlqtygehypldhfdk

Timeline for d1dtwa_:

• d1dtwa_ first appeared (with stable ids) in SCOP 1.55, called d1dtwa1
  
• d1dtwa_ appears in SCOPe 2.07