Lineage for d5f01a_ (5f01 A:)

  1. Root: SCOPe 2.07
  2. 2352458Class b: All beta proteins [48724] (178 folds)
  3. 2408655Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2408656Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2410318Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2410376Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2410377Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2410464Domain d5f01a_: 5f01 A: [313849]
    automated match to d1fkna_
    complexed with 5t7, act, dms, gol, na

Details for d5f01a_

PDB Entry: 5f01 (more details), 1.52 Å

PDB Description: crystal structure of bace-1 in complex with (1sr,2sr)-2-((r)-2-amino- 5,5-difluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-n-(3- chloroquinolin-8-yl)cyclopropanecarboxamide
PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d5f01a_:

Sequence, based on SEQRES records: (download)

>d5f01a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records): (download)

>d5f01a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplasvggsmiiggidh
slytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvf
eaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritil
pqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachv
hdefrtaavegpfvtldmedcgyn

SCOPe Domain Coordinates for d5f01a_:

Click to download the PDB-style file with coordinates for d5f01a_.
(The format of our PDB-style files is described here.)

Timeline for d5f01a_: