SCOPe 2.06: Domain d4b1ia_: 4b1i A:

Lineage for d4b1ia_ (4b1i A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein automated matches [310881] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [311355] (6 PDB entries)

8. Domain d4b1ia_: 4b1i A: [307036]
   automated match to d3ueka_
   complexed with a8p, dtv, gol, so4

Details for d4b1ia_

PDB Entry: 4b1i, 2.14 Å

PDB Description: structure of human parg catalytic domain in complex with oa-adp-hpd

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d4b1ia_:

Sequence, based on SEQRES records:

>d4b1ia_ c.50.1.3 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwd
ftalidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeq
iasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaa
aptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvts
aglvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgs
erddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgn
wgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvy
klllryyneecrncstpgpdiklypfiyhavesc

Sequence, based on observed residues (ATOM records):

>d4b1ia_ c.50.1.3 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvtagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllan
affctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvt
ftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqee
irflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqr
rcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafg
gdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryy
neecrncstpgpdiklypfiyhavesc

Timeline for d4b1ia_:

• d4b1ia_ is new in SCOPe 2.06-stable
  
• d4b1ia_ appears in SCOPe 2.07
  
• d4b1ia_ appears in the current release, SCOPe 2.08