Lineage for d1bzla1 (1bzl A:2-169,A:287-357)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2849308Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. 2849309Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families) (S)
  5. 2849878Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
    duplication: both domains have similar folds and functions
    most members of the family contain common C-terminal alpha+beta domain
  6. 2850224Protein Trypanothione reductase, N- and C-terminal domain [418954] (3 species)
  7. 2850243Species Trypanosoma cruzi [TaxId:5693] [419414] (4 PDB entries)
  8. 2850246Domain d1bzla1: 1bzl A:2-169,A:287-357 [30521]
    Other proteins in same PDB: d1bzla2, d1bzla3, d1bzlb2, d1bzlb3
    complexed with fad, gcg
    has additional insertions and/or extensions that are not grouped together

Details for d1bzla1

PDB Entry: 1bzl (more details), 2.4 Å

PDB Description: crystal structure of trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
PDB Compounds: (A:) trypanothione reductase (oxidized form)

SCOPe Domain Sequences for d1bzla1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1bzla1 c.3.1.5 (A:2-169,A:287-357) Trypanothione reductase, N- and C-terminal domain {Trypanosoma cruzi [TaxId: 5693]}

SCOPe Domain Coordinates for d1bzla1:

Click to download the PDB-style file with coordinates for d1bzla1.
(The format of our PDB-style files is described here.)

Timeline for d1bzla1: