Lineage for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families) (S)
  5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
    duplication: both domains have similar folds and functions
    most members of the family contain common C-terminal alpha+beta domain

Proteins:

  1. Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains [51953] (2 species)
    1. Species Escherichia coli [TaxId:562] [63949] (1 PDB entry)
    2. Species Salmonella typhimurium [TaxId:90371] [51954] (1 PDB entry)
  2. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [51966] (1 species)
    has a smaller C-terminal alpha+beta domain instead the "interface" domain
  3. NADH oxidase /nitrite reductase [117442] (1 species)
  4. Phenylacetone monooxygenase [110440] (1 species)
  5. Thioredoxin reductase [51950] (2 species)
    lacks the "interface" C-terminal alpha+beta domain
    1. Species Escherichia coli [TaxId:562] [51951] (5 PDB entries)
    2. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [51952] (1 PDB entry)
  6. Apoptosis-inducing factor (AIF), N- and C-terminal domain [418936] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [419374] (2 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [419376] (1 PDB entry)
  7. Apoptosis-inducing factor (AIF), middle domain [418937] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [419375] (2 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [419377] (1 PDB entry)
  8. Dihydrolipoamide dehydrogenase, N- and C-terminal domain [418938] (8 species)
    1. Species Mycobacterium tuberculosis [TaxId:1773] [117441] (1 PDB entry)
      Uniprot O53355
    2. Species Azotobacter vinelandii [TaxId:354] [419378] (1 PDB entry)
    3. Species Bacillus stearothermophilus [TaxId:1422] [419380] (1 PDB entry)
    4. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [419382] (2 PDB entries)
    5. Species Neisseria meningitidis [TaxId:487] [419384] (2 PDB entries)
    6. Species Pea (Pisum sativum) [TaxId:3888] [419386] (1 PDB entry)
    7. Species Pseudomonas fluorescens [TaxId:294] [419388] (1 PDB entry)
    8. Species Pseudomonas putida [TaxId:303] [419390] (1 PDB entry)
  9. Dihydrolipoamide dehydrogenase, middle domain [418939] (7 species)
    1. Species Azotobacter vinelandii [TaxId:354] [419379] (1 PDB entry)
    2. Species Bacillus stearothermophilus [TaxId:1422] [419381] (1 PDB entry)
    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [419383] (2 PDB entries)
    4. Species Neisseria meningitidis [TaxId:487] [419385] (2 PDB entries)
    5. Species Pea (Pisum sativum) [TaxId:3888] [419387] (1 PDB entry)
    6. Species Pseudomonas fluorescens [TaxId:294] [419389] (1 PDB entry)
    7. Species Pseudomonas putida [TaxId:303] [419391] (1 PDB entry)
  10. Flavin-dependent monoxygenase SPBP16F5.08c, N- and C-terminal domain [418940] (1 species)
  11. Flavin-dependent monoxygenase SPBP16F5.08c, middle domain [418941] (1 species)
  12. Glutathione reductase, N- and C-terminal domain [418942] (3 species)
    1. Species Escherichia coli [TaxId:562] [419394] (4 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [419396] (23 PDB entries)
    3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [419398] (1 PDB entry)
  13. Glutathione reductase, middle domain [418943] (3 species)
    1. Species Escherichia coli [TaxId:562] [419395] (4 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [419397] (23 PDB entries)
    3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [419399] (1 PDB entry)
  14. Mammalian thioredoxin reductase, N- and C-terminal domain [418944] (1 species)
  15. Mammalian thioredoxin reductase, middle domain [418945] (1 species)
  16. NADH peroxidase, N- and C-terminal domain [418946] (1 species)
  17. NADH peroxidase, middle domain [418947] (1 species)
  18. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase, N- and C-terminal domain [418948] (1 species)
  19. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase, middle domain [418949] (1 species)
  20. NADH-dependent ferredoxin reductase, BphA4, N- and C-terminal domain [418950] (1 species)
  21. NADH-dependent ferredoxin reductase, BphA4, middle domain [418951] (1 species)
  22. Putidaredoxin reductase, N- and C-terminal domain [418952] (1 species)
  23. Putidaredoxin reductase, middle domain [418953] (1 species)
  24. Trypanothione reductase, N- and C-terminal domain [418954] (3 species)
    1. Species Crithidia fasciculata [TaxId:5656] [419410] (6 PDB entries)
    2. Species Leishmania infantum [TaxId:5671] [419412] (1 PDB entry)
    3. Species Trypanosoma cruzi [TaxId:5693] [419414] (4 PDB entries)
  25. Trypanothione reductase, middle domain [418955] (3 species)
    1. Species Crithidia fasciculata [TaxId:5656] [419411] (6 PDB entries)
    2. Species Leishmania infantum [TaxId:5671] [419413] (1 PDB entry)
    3. Species Trypanosoma cruzi [TaxId:5693] [419415] (4 PDB entries)

More info for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

Timeline for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains: