Lineage for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2096453Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. 2096454Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families) (S)
  5. 2096984Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (15 protein domains)
    duplication: both domains have similar folds and functions
    most members of the family contain common C-terminal alpha+beta domain

Protein Domains:

  1. 2096985Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains [51953] (2 species)
    1. 2096986Species Escherichia coli [TaxId:562] [63949] (1 PDB entry)
    2. 2096989Species Salmonella typhimurium [TaxId:90371] [51954] (1 PDB entry)
  2. 2096992Apoptosis-inducing factor (AIF) [75126] (2 species)
    1. 2096993Species Human (Homo sapiens) [TaxId:9606] [75127] (2 PDB entries)
    2. 2096998Species Mouse (Mus musculus) [TaxId:10090] [75128] (1 PDB entry)
  3. 2097003Dihydrolipoamide dehydrogenase [51959] (8 species)
    1. 2097004Species Azotobacter vinelandii [TaxId:354] [51962] (1 PDB entry)
    2. 2097009Species Bacillus stearothermophilus [TaxId:1422] [51963] (1 PDB entry)
    3. 2097014Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [63950] (2 PDB entries)
    4. 2097023Species Mycobacterium tuberculosis [TaxId:1773] [117441] (1 PDB entry)
      Uniprot O53355
    5. 2097026Species Neisseria meningitidis [TaxId:487] [51964] (2 PDB entries)
    6. 2097031Species Pea (Pisum sativum) [TaxId:3888] [51965] (1 PDB entry)
    7. 2097040Species Pseudomonas fluorescens [TaxId:294] [51961] (1 PDB entry)
    8. 2097045Species Pseudomonas putida [TaxId:303] [51960] (1 PDB entry)
  4. 2097048Flavin-dependent monoxygenase SPBP16F5.08c [117444] (1 species)
  5. 2097066Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [51966] (1 species)
    has a smaller C-terminal alpha+beta domain instead the "interface" domain
  6. 2097072Glutathione reductase [51944] (3 species)
    1. 2097073Species Escherichia coli [TaxId:562] [51946] (4 PDB entries)
    2. 2097090Species Human (Homo sapiens) [TaxId:9606] [51945] (23 PDB entries)
    3. 2097141Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [89548] (1 PDB entry)
  7. 2097144Mammalian thioredoxin reductase [63947] (1 species)
  8. 2097158NADH oxidase /nitrite reductase [117442] (1 species)
  9. 2097162NADH peroxidase [51955] (1 species)
  10. 2097180NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82313] (1 species)
  11. 2097206NADH-dependent ferredoxin reductase, BphA4 [51957] (1 species)
  12. 2097228Phenylacetone monooxygenase [110440] (1 species)
  13. 2097242Putidaredoxin reductase [102185] (1 species)
  14. 2097252Thioredoxin reductase [51950] (2 species)
    lacks the "interface" C-terminal alpha+beta domain
    1. 2097253Species Escherichia coli [TaxId:562] [51951] (5 PDB entries)
    2. 2097270Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [51952] (1 PDB entry)
  15. 2097273Trypanothione reductase [51947] (3 species)
    1. 2097274Species Crithidia fasciculata [TaxId:5656] [51948] (6 PDB entries)
    2. 2097303Species Leishmania infantum [TaxId:5671] [267748] (1 PDB entry)
    3. 2097308Species Trypanosoma cruzi [TaxId:5693] [51949] (4 PDB entries)

More info for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains

Timeline for Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains: