SCOPe 2.02: Domain d1fdvc_: 1fdv C:

Lineage for d1fdvc_ (1fdv C:)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (16 PDB entries)
   Uniprot P14061

8. Domain d1fdvc_: 1fdv C: [29854]
   complexed with nad, so4; mutant

Details for d1fdvc_

PDB Entry: 1fdv, 3.1 Å

PDB Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221l complexed with nad+

PDB Compounds: (C:) 17-beta-hydroxysteroid dehydrogenase

SCOPe Domain Sequences for d1fdvc_:

Sequence; same for both SEQRES and ATOM records:

>d1fdvc_ c.2.1.2 (C:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfg

Timeline for d1fdvc_:

• d1fdvc_ first appeared (with stable ids) in SCOP 1.55
  
• d1fdvc_ appears in SCOPe 2.01
  
• d1fdvc_ appears in SCOPe 2.03
  
• d1fdvc_ appears in the current release, SCOPe 2.08