SCOPe 2.07: Domain d5edqa_: 5edq A:

Lineage for d5edqa_ (5edq A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (129 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5edqa_: 5edq A: [279747]
   automated match to d4li5a_
   complexed with 5n3

Details for d5edqa_

PDB Entry: 5edq, 2.8 Å

PDB Description: egfr kinase (t790m/l858r) with inhibitor compound 15: ~{n}-(7- chloranyl-1~{h}-indazol-3-yl)-7,7-dimethyl-2-(1~{h}-pyrazol-4-yl)- 5~{h}-furo[3,4-d]pyrimidin-4-amine

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5edqa_:

Sequence, based on SEQRES records:

>d5edqa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d5edqa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgravpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfdmddvvdadeyli

Timeline for d5edqa_:

• d5edqa_ first appeared in SCOPe 2.05
  
• d5edqa_ appears in SCOPe 2.06
  
• d5edqa_ appears in the current release, SCOPe 2.08