SCOPe 2.07: Domain d4rygb_: 4ryg B:

Lineage for d4rygb_ (4ryg B:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)

8. Domain d4rygb_: 4ryg B: [270430]
   automated match to d2rena_
   complexed with 3zj, dms, nag, so4

Details for d4rygb_

PDB Entry: 4ryg, 2.65 Å

PDB Description: renin in complexed with n-({(3s,4s)-4-[(benzylsulfonyl) amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-n- (propan-2-yl)benzamide inhibitor

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d4rygb_:

Sequence, based on SEQRES records:

>d4rygb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d4rygb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d4rygb_:

• d4rygb_ first appeared in SCOPe 2.05
  
• d4rygb_ appears in SCOPe 2.06
  
• d4rygb_ appears in the current release, SCOPe 2.08