SCOPe 2.08: Domain d4o1ub_: 4o1u B:

Lineage for d4o1ub_ (4o1u B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189245] (10 PDB entries)

8. Domain d4o1ub_: 4o1u B: [268435]
   automated match to d4eb4a_
   complexed with cl, edo, so4; mutant

Details for d4o1ub_

PDB Entry: 4o1u, 2.26 Å

PDB Description: Crystal structure of human thymidylate synthase mutant Y202C

PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d4o1ub_:

Sequence, based on SEQRES records:

>d4o1ub_ d.117.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfcvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records):

>d4o1ub_ d.117.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelssdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktn
pddrriimcawnprdlplmalppchalcqfcvvnselscqlyqrsgdmglgvpfniasya
lltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddf
kaedfqiegynphptikme

Timeline for d4o1ub_:

• d4o1ub_ first appeared in SCOPe 2.05
  
• d4o1ub_ appears in SCOPe 2.07