Lineage for d4npva_ (4npv A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2014835Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2014836Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2014926Family a.211.1.2: PDEase [48548] (7 protein domains)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 2015191Protein automated matches [190370] (1 species)
    not a true protein
  7. 2015192Species Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries)
  8. 2015217Domain d4npva_: 4npv A: [257992]
    automated match to d1taza_
    complexed with 0nk, mg, zn

Details for d4npva_

PDB Entry: 4npv (more details), 2.4 Å

PDB Description: Crystal structure of human PDE1B bound to inhibitor 7A (6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine)
PDB Compounds: (A:) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

SCOPe Domain Sequences for d4npva_:

Sequence, based on SEQRES records: (download)

>d4npva_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
stavlnclknldlwcfdvfslnqaaddhalrtivfelltrhnlisrfkiptvflmsflda
letgygkyknpyhnqihaadvtqtvhcfllrtgmvhclseiellaiifaaaihdyehtgt
tnsfhiqtksecaivyndrsvlenhhissvfrlmqddemnifinltkdefvelralviem
vlatdmschfqqvktmktalqqleridkpkalslllhaadishptkqwlvhsrwtkalme
effrqgdkeaelglpfsplcdrtstlvaqsqigfidfiveptfsvltdvaeksvqplade
dsksknqpsfqwrqpsldvevgdpnpdvvsfrstwvkriqenkqkwkeraas

Sequence, based on observed residues (ATOM records): (download)

>d4npva_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
stavlnclknldlwcfdvfslnqaaddhalrtivfelltrhnlisrfkiptvflmsflda
letgygkyknpyhnqihaadvtqtvhcfllrtgmvhclseiellaiifaaaihdyehtgt
tnsfhiqtksecaivyndrsvlenhhissvfrlmqddemnifinltkdefvelralviem
vlatdmschfqqvktmktalqqleridkpkalslllhaadishptkqwlvhsrwtkalme
effrqgdkeaelglpfsplcdrtstlvaqsqigfidfiveptfsvltdvaeksvqppdvv
sfrstwvkriqenkqkwkeraas

SCOPe Domain Coordinates for d4npva_:

Click to download the PDB-style file with coordinates for d4npva_.
(The format of our PDB-style files is described here.)

Timeline for d4npva_: