SCOPe 2.08: Domain d4mpea2: 4mpe A:182-394

Lineage for d4mpea2 (4mpe A:182-394)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (19 PDB entries)
   Uniprot Q15120 177-301

8. Domain d4mpea2: 4mpe A:182-394 [253824]
   Other proteins in same PDB: d4mpea1
   automated match to d2bu8a2
   complexed with pv8, tla

Details for d4mpea2

PDB Entry: 4mpe, 1.95 Å

PDB Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d4mpea2:

Sequence, based on SEQRES records:

>d4mpea2 d.122.1.4 (A:182-394) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylk
alstdsverlpvynksawrhyqtiqeagdwcvp

Sequence, based on observed residues (ATOM records):

>d4mpea2 d.122.1.4 (A:182-394) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynks
awrhyqtiqeagdwcvp

Timeline for d4mpea2:

• d4mpea2 first appeared in SCOPe 2.04
  
• d4mpea2 appears in SCOPe 2.07