SCOPe 2.08: Domain d4c66a1: 4c66 A:44-167

Lineage for d4c66a1 (4c66 A:44-167)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (15 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)

8. Domain d4c66a1: 4c66 A:44-167 [251343]
   Other proteins in same PDB: d4c66a2
   automated match to d3g0la_
   complexed with h4c

Details for d4c66a1

PDB Entry: 4c66, 1.87 Å

PDB Description: Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4c66a1:

Sequence; same for both SEQRES and ATOM records:

>d4c66a1 a.29.2.0 (A:44-167) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpte

Timeline for d4c66a1:

• d4c66a1 first appeared in SCOPe 2.04, called d4c66a_
  
• d4c66a1 appears in SCOPe 2.07