SCOPe 2.04: Domain d3exgm_: 3exg M:

Lineage for d3exgm_ (3exg M:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89652] (7 PDB entries)

8. Domain d3exgm_: 3exg M: [245967]
   Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
   automated match to d3exia_
   complexed with k

Details for d3exgm_

PDB Entry: 3exg, 3.01 Å

PDB Description: crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex

PDB Compounds: (M:) Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

SCOPe Domain Sequences for d3exgm_:

Sequence, based on SEQRES records:

>d3exgm_ c.36.1.11 (M:) E1-beta subunit of pyruvate dehydrogenase (PP module) {Human (Homo sapiens) [TaxId: 9606]}
mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtaveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs

Sequence, based on observed residues (ATOM records):

>d3exgm_ c.36.1.11 (M:) E1-beta subunit of pyruvate dehydrogenase (PP module) {Human (Homo sapiens) [TaxId: 9606]}
mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrraaastdyykrgdfipglrvdgmdilcvreatrfaaaycrsg
kgpilmelqtyryhdpgvayrtreeiqevrsksdpimllkdrmvnsnlasveelkeidve
vrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfksvs

Timeline for d3exgm_:

• d3exgm_ is new in SCOPe 2.04-stable
  
• d3exgm_ appears in SCOPe 2.05
  
• d3exgm_ appears in the current release, SCOPe 2.08, called d3exgm1