SCOPe 2.04: Domain d3apda3: 3apd A:546-725

Lineage for d3apda3 (3apd A:546-725)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (24 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (26 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (57 PDB entries)

8. Domain d3apda3: 3apd A:546-725 [245178]
   Other proteins in same PDB: d3apda1, d3apda2, d3apda4
   automated match to d1e7ua1
   complexed with mmy, so4

Details for d3apda3

PDB Entry: 3apd, 2.55 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with CH5108134

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3apda3:

Sequence; same for both SEQRES and ATOM records:

>d3apda3 a.118.1.6 (A:546-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
empnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeiva
ktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvq
avkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcg

Timeline for d3apda3:

• d3apda3 is new in SCOPe 2.04-stable
  
• d3apda3 appears in SCOPe 2.05
  
• d3apda3 appears in the current release, SCOPe 2.08