SCOPe 2.07: Domain d2xpca2: 2xpc A:94-297

Lineage for d2xpca2 (2xpc A:94-297)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.72: Ribokinase-like [53612] (3 superfamilies)
   core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
   potential superfamily: members of this fold have similar functions but different ATP-binding sites

4. Superfamily c.72.2: MurD-like peptide ligases, catalytic domain [53623] (3 families)
   has extra strand located between strands 1 and 2

5. Family c.72.2.1: MurCDEF [53624] (5 protein domains)
   automatically mapped to Pfam PF08245

6. Protein automated matches [254549] (3 species)
   not a true protein

7. Species Escherichia coli [TaxId:562] [255258] (8 PDB entries)

8. Domain d2xpca2: 2xpc A:94-297 [244566]
   Other proteins in same PDB: d2xpca1, d2xpca3, d2xpca4
   automated match to d4uaga3
   complexed with 051, cl, dms, so4

Details for d2xpca2

PDB Entry: 2xpc, 1.49 Å

PDB Description: second-generation sulfonamide inhibitors of murd: activity optimisation with conformationally rigid analogues of d-glutamic acid

PDB Compounds: (A:) udp-n-acetylmuramoylalanine--d-glutamate ligase

SCOPe Domain Sequences for d2xpca2:

Sequence, based on SEQRES records:

>d2xpca2 c.72.2.1 (A:94-297) automated matches {Escherichia coli [TaxId: 562]}
dielfcreaqapivaitgsngkstvttlvgemakaagvnvgvggniglpalmllddecel
yvlelssfqlettsslqavaatilnvtedhmdrypfglqqyraaklriyenakvcvvnad
daltmpirgadercvsfgvnmgdyhlnhqqgetwlrvkgekvlnvkemklsgqhnytnal
aalaladaaglprasslkalttft

Sequence, based on observed residues (ATOM records):

>d2xpca2 c.72.2.1 (A:94-297) automated matches {Escherichia coli [TaxId: 562]}
dielfcreaqapivaitgsngkstvttlvgemakaagvnvgvggniglpalmllddecel
yvlelssfqlettsslqavaatilnvtedhmdrypfglqqyraaklriyenakvcvvnad
daltmpirrcvsfgvnmgdyhlnhqqgetwlrvkgekvlnvkemklsgqhnytnalaala
ladaaglprasslkalttft

Timeline for d2xpca2:

• d2xpca2 first appeared in SCOPe 2.04
  
• d2xpca2 appears in SCOPe 2.06