PDB entry 2xpc
View 2xpc on RCSB PDB site
Description: Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid
Class: ligase
Keywords: ligase, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase synthesis
Deposited on
2010-08-26, released
2011-05-18
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-02-07, with a file datestamp of
2018-02-02.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: N/A
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: udp-n-acetylmuramoylalanine--d-glutamate ligase
Species: Escherichia coli [TaxId:562]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8X9Y9 (0-436)
- conflict (373)
- expression tag (437-438)
Domains in SCOPe 2.08: d2xpca1, d2xpca2, d2xpca3, d2xpca4 - Heterogens: 051, DMS, SO4, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xpcA (A:)
adyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnde
wlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvtt
lvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnvt
edhmdrypfglqqyraaklriyenakvcvvnaddaltmpirgadercvsfgvnmgdyhln
hqqgetwlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftglp
hrfevvlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplaryln
gdnvrlycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqfk
nfeqrgnefarlakelgsh
Sequence, based on observed residues (ATOM records): (download)
>2xpcA (A:)
adyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnde
wlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvtt
lvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnvt
edhmdrypfglqqyraaklriyenakvcvvnaddaltmpirrcvsfgvnmgdyhlnhqqg
etwlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftglphrfe
vvlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplarylngdnv
rlycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqfknfeq
rgnefarlakelgsh