SCOPe 2.08: Domain d2w7xa_: 2w7x A:

Lineage for d2w7xa_ (2w7x A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d2w7xa_: 2w7x A: [244031]
   automated match to d2w0ja_
   complexed with d1a, edo, mg, no3

Details for d2w7xa_

PDB Entry: 2w7x, 2.07 Å

PDB Description: cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel chk2 inhibitor pv1019

PDB Compounds: (A:) serine/threonine-protein kinase chk2

SCOPe Domain Sequences for d2w7xa_:

Sequence, based on SEQRES records:

>d2w7xa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpaln
veteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfy
qmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtpt
ylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfip
evwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestalp
q

Sequence, based on observed residues (ATOM records):

>d2w7xa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlgsgagevklaferktckkvaikiisknveteieilkklnhpci
ikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiih
rdlkpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagyn
ravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkk
llvvdpkarftteealrhpwlqdedmkrkfqdllseenestalpq

Timeline for d2w7xa_:

• d2w7xa_ first appeared in SCOPe 2.04
  
• d2w7xa_ appears in SCOPe 2.07