PDB entry 2w7x
View 2w7x on RCSB PDB site
Description: cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel chk2 inhibitor pv1019
Class: transferase
Keywords: co-crystal structure, kinase, nucleus, magnesium, cell cycle, ATP-binding, li-fraumeni syndrome, serine/threonine-protein kinase, disease mutation, nucleotide-binding, transferase, potentiation, metal-binding, proto-oncogene, phosphoprotein, chk2 inhibitor
Deposited on
2009-01-06, released
2009-09-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-13, with a file datestamp of
2011-06-02.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: 0.195
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine-protein kinase chk2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2W7X
- Uniprot O96017 (1-End)
Domains in SCOPe 2.08: d2w7xa_ - Heterogens: D1A, MG, NO3, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2w7xA (A:)
msvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpal
nveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyf
yqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtp
tylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfi
pevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestal
pqvlaqpstsrkrpregeaegae
Sequence, based on observed residues (ATOM records): (download)
>2w7xA (A:)
svypkalrdeyimsktlgsgagevklaferktckkvaikiisknveteieilkklnhpci
ikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiih
rdlkpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagyn
ravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkk
llvvdpkarftteealrhpwlqdedmkrkfqdllseenestalpq