SCOPe 2.03: Domain d3w2ra_: 3w2r A:

Lineage for d3w2ra_ (3w2r A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (38 PDB entries)
   Uniprot P00533 702-1018

8. Domain d3w2ra_: 3w2r A: [233923]
   automated match to d3w2oa_
   complexed with edo, w2r; mutant

Details for d3w2ra_

PDB Entry: 3w2r, 2.05 Å

PDB Description: egfr kinase domain t790m/l858r mutant with compound 4

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3w2ra_:

Sequence, based on SEQRES records:

>d3w2ra_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnf
yralmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records):

>d3w2ra_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriy
thqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcw
midadsrpkfreliiefskmardpqrylviqgdesnfyralmdeedmddvvdadeyl

Timeline for d3w2ra_:

• d3w2ra_ is new in SCOPe 2.03-stable
  
• d3w2ra_ appears in SCOPe 2.04
  
• d3w2ra_ appears in the current release, SCOPe 2.08