SCOPe 2.06: Domain d1e90a2: 1e90 A:357-521

Lineage for d1e90a2 (1e90 A:357-521)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [49571] (6 PDB entries)

8. Domain d1e90a2: 1e90 A:357-521 [23185]
   Other proteins in same PDB: d1e90a1, d1e90a3, d1e90a4, d1e90a5
   complexed with myc

Details for d1e90a2

PDB Entry: 1e90, 2.7 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOPe Domain Sequences for d1e90a2:

Sequence, based on SEQRES records:

>d1e90a2 b.7.1.1 (A:357-521) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
cdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkapalsgktsaempspeskgkaqllyyvnlllidhrfllr
hgeyvlhmwqlsgkgedqgsfnadkltsatnpdkensmsisilld

Sequence, based on observed residues (ATOM records):

>d1e90a2 b.7.1.1 (A:357-521) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
cdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycqllyyvnlllidhrfllrhgeyvlhmwqlsfnadkltsatn
pdkensmsisilld

Timeline for d1e90a2:

• d1e90a2 first appeared (with stable ids) in SCOP 1.55
  
• d1e90a2 appears in SCOPe 2.05
  
• d1e90a2 appears in SCOPe 2.07
  
• d1e90a2 appears in the current release, SCOPe 2.08