SCOPe 2.04: Domain d1e7va2: 1e7v A:354-524

Lineage for d1e7va2 (1e7v A:354-524)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [49571] (5 PDB entries)

8. Domain d1e7va2: 1e7v A:354-524 [23184]
   Other proteins in same PDB: d1e7va1, d1e7va3, d1e7va4
   complexed with ly2

Details for d1e7va2

PDB Entry: 1e7v, 2.4 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOPe Domain Sequences for d1e7va2:

Sequence, based on SEQRES records:

>d1e7va2 b.7.1.1 (A:354-524) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
lwdcdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvw
lefsikikdlpkgallnlqiycgkapalsgktsaempspeskgkaqllyyvnlllidhrf
llrhgeyvlhmwqlsgkgedqgsfnadkltsatnpdkensmsisilldnyc

Sequence, based on observed residues (ATOM records):

>d1e7va2 b.7.1.1 (A:354-524) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
lwdcdrkfrvkirgidipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvw
lefsikikdlpkgallnlqiycqllyyvnlllidhrfllrhgeyvlhmwqlsfnadklts
atnpdkensmsisilldnyc

Timeline for d1e7va2:

• d1e7va2 first appeared (with stable ids) in SCOP 1.55
  
• d1e7va2 appears in SCOPe 2.03
  
• d1e7va2 appears in SCOPe 2.05
  
• d1e7va2 appears in the current release, SCOPe 2.08