SCOPe 2.05: Domain d4ia0a_: 4ia0 A:

Lineage for d4ia0a_ (4ia0 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (26 PDB entries)

8. Domain d4ia0a_: 4ia0 A: [230251]
   automated match to d3tsea_
   complexed with 5bb, mg, zn

Details for d4ia0a_

PDB Entry: 4ia0, 2.17 Å

PDB Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4ia0a_:

Sequence, based on SEQRES records:

>d4ia0a_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalae

Sequence, based on observed residues (ATOM records):

>d4ia0a_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsqlychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatd
lalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvat
effdnkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalae

Timeline for d4ia0a_:

• d4ia0a_ first appeared in SCOPe 2.03
  
• d4ia0a_ appears in SCOPe 2.04
  
• d4ia0a_ appears in SCOPe 2.06
  
• d4ia0a_ appears in the current release, SCOPe 2.08