SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class a: All alpha proteins

  1. Root: SCOPe 2.05
  2. 1715731Class a: All alpha proteins [46456] (286 folds)

Folds:

  1. 1715732a.1: Globin-like [46457] (2 superfamilies)
    core: 6 helices; folded leaf, partly opened
  2. 1718782a.2: Long alpha-hairpin [46556] (20 superfamilies)
    2 helices; antiparallel hairpin, left-handed twist
  3. 1719636a.3: Cytochrome c [46625] (1 superfamily)
    core: 3 helices; folded leaf, opened
  4. 1720410a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  5. 1723911a.5: RuvA C-terminal domain-like [46928] (9 superfamilies)
    3 helices; bundle, right-handed twist
  6. 1724238a.6: Putative DNA-binding domain [46954] (1 superfamily)
    core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
  7. 1724371a.7: Spectrin repeat-like [46965] (16 superfamilies)
    3 helices; bundle, closed, left-handed twist; up-and-down
  8. 1724803a.8: immunoglobulin/albumin-binding domain-like [46996] (11 superfamilies)
    3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
  9. 1725096a.9: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1 superfamily)
    3 helices; bundle, closed, right-handed twist; up-and-down
  10. 1725145a.10: Protozoan pheromone-like [47013] (2 superfamilies)
    3 helices; bundle, closed, left-handed twist, up-and-down
  11. 1725169a.11: Acyl-CoA binding protein-like [47026] (2 superfamilies)
    core: 3 helices; bundle, closed, left-handed twist; up-and-down
  12. 1725314a.12: Kix domain of CBP (creb binding protein) [47039] (1 superfamily)
    3 helices; bundle, partly opened
  13. 1725328a.13: RAP domain-like [47044] (1 superfamily)
    3 helices, the first one is shorter than the other two; bundle, partly opened
  14. 1725340a.14: VHP, Villin headpiece domain [47049] (1 superfamily)
    3 short helices; irregular array
  15. 1725381a.15: TAF(II)230 TBP-binding fragment [47054] (1 superfamily)
    3 short helices; irregular array
  16. 1725387a.16: S15/NS1 RNA-binding domain [47059] (1 superfamily)
    3 helices; irregular array
  17. 1725503a.17: Cysteine alpha-hairpin motif [47071] (1 superfamily)
    core: alpha-hairpin crosslinked with two disulfides
  18. 1725518a.18: T4 endonuclease V [47076] (1 superfamily)
    3 helices; irregular array
  19. 1725530a.19: Fertilization protein [47081] (1 superfamily)
    core: 3 helices; bundle, closed, right-handed twist; up-and-down
  20. 1725549a.20: PGBD-like [47089] (1 superfamily)
    core: 3 helices; bundle, closed, left-handed twist; parallel
  21. 1725579a.21: HMG-box [47094] (1 superfamily)
    3 helices; irregular array
  22. 1725671a.22: Histone-fold [47112] (1 superfamily)
    core: 3 helices; long middle helix is flanked at each end with shorter ones
  23. 1726377a.23: Open three-helical up-and-down bundle [47143] (7 superfamilies)
    core: 3 helices; bundle, open
  24. 1726514a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
  25. 1727563a.25: Ferritin-like [47239] (6 superfamilies)
    core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
  26. 1730528a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  27. 1730937a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily)
    core: 4 helices; bundle; one loop crosses over one side of the bundle
  28. 1731061a.28: Acyl carrier protein-like [47335] (3 superfamilies)
    4 helices, bundle; helix 3 is shorter than others; up-and-down
  29. 1731436a.29: Bromodomain-like [47363] (15 superfamilies)
    4 helices; bundle; minor mirror variant of up-and-down topology
  30. 1732492a.30: ROP-like [47379] (8 superfamilies)
    4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
  31. 1732610a.31: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  32. 1732657a.32: Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  33. 1732673a.33: Ectatomin subunits [47400] (1 superfamily)
    4 helices; bundle, closed, left-handed twist
  34. 1732682a.34: Dimerisation interlock [47405] (4 superfamilies)
    4 helices; bundle, closed, right-handed twist
  35. 1732724a.35: lambda repressor-like DNA-binding domains [47412] (1 superfamily)
    core: 4 helices; folded leaf, closed
  36. 1733267a.36: Signal peptide-binding domain [47445] (1 superfamily)
    4 helices; orthogonal array
  37. 1733307a.37: A DNA-binding domain in eukaryotic transcription factors [47453] (1 superfamily)
    4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
  38. 1733316a.38: HLH-like [47458] (2 superfamilies)
    4-helices; bundle, closed, left-handed twist; 2 crossover connections
  39. 1733371a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  40. 1734996a.40: CH domain-like [47575] (3 superfamilies)
    core: 4 helices: bundle
  41. 1735148a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
    core: 4 helices: bundle; unusual topology
  42. 1735235a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  43. 1735385a.43: Ribbon-helix-helix [47597] (1 superfamily)
    core: 4 helices; array of 2 hairpins, opened
  44. 1735625a.45: GST C-terminal domain-like [47615] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
  45. 1736770a.46: Methionine synthase domain-like [47643] (3 superfamilies)
    4 helices; bundle, left-handed twist; right-handed superhelix
  46. 1736856a.47: STAT-like [47654] (6 superfamilies)
    4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
  47. 1736945a.48: N-cbl like [47667] (5 superfamilies)
    4 helices; bundle, left-handed twist; left-handed superhelix
  48. 1737046a.49: C-terminal domain of B transposition protein [47680] (1 superfamily)
    4 helices; irregular array
  49. 1737052a.50: Anaphylotoxins (complement system) [47685] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  50. 1737085a.51: Cytochrome c oxidase subunit h [47693] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  51. 1737146a.52: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1 superfamily)
    4 helices; folded leaf; right-handed superhelix
  52. 1737237a.53: p53 tetramerization domain [47718] (1 superfamily)
    core: 4 helices; bundle
  53. 1737323a.54: Domain of early E2A DNA-binding protein, ADDBP [47723] (1 superfamily)
    4 helices; bundle, partly opened
  54. 1737334a.55: IHF-like DNA-binding proteins [47728] (1 superfamily)
    core: 4 helices; bundle, partly opened, capped with a beta-sheet
  55. 1737421a.56: CO dehydrogenase ISP C-domain like [47740] (1 superfamily)
    core: 4 helices, bundle
  56. 1737537a.57: Protein HNS-dependent expression A; HdeA [47751] (1 superfamily)
    4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
  57. 1737551a.58: Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1 superfamily)
    4 helices; an orthogonal array
  58. 1737558a.59: PAH2 domain [47761] (1 superfamily)
    4 helices; open up-and-down bundle; binds alpha-helical peptides
  59. 1737577a.60: SAM domain-like [47768] (16 superfamilies)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  60. 1738766a.61: Retroviral matrix proteins [47835] (1 superfamily)
    4-5 helices; right-handed superhelix
  61. 1738833a.62: Hepatitis B viral capsid (hbcag) [47851] (1 superfamily)
    5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
  62. 1738864a.63: Apolipophorin-III [47856] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  63. 1738873a.64: Saposin-like [47861] (2 superfamilies)
    5 helices; folded leaf, closed
  64. 1738953a.65: Annexin [47873] (1 superfamily)
    5 helices; folded leaf, closed
  65. 1739075a.66: Transducin (alpha subunit), insertion domain [47894] (1 superfamily)
    5 helices; folded leaf
  66. 1739152a.68: Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1 superfamily)
    5 helices; irregular array; left-handed superhelix
  67. 1739159a.69: Left-handed superhelix [47916] (4 superfamilies)
    core: 4-5 helices; bundle; left-handed superhelix
  68. 1739438a.70: ATPD N-terminal domain-like [47927] (2 superfamilies)
    core: 5 helices; bundle
  69. 1739455a.71: ERP29 C domain-like [47932] (2 superfamilies)
    5 helices; bundle
  70. 1739489a.72: Functional domain of the splicing factor Prp18 [47937] (1 superfamily)
    core: 5 helices; bundle
  71. 1739496a.73: Retrovirus capsid protein, N-terminal core domain [47942] (1 superfamily)
    core: 5 helices; bundle
  72. 1739685a.74: Cyclin-like [47953] (1 superfamily)
    core: 5 helices; one helix is surrounded by the others
  73. 1740240a.75: Ribosomal protein S7 [47972] (1 superfamily)
    core: 5 helices; contains one more helix and a beta-hairpin outside the core
  74. 1740321a.76: Iron-dependent repressor protein, dimerization domain [47978] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  75. 1740429a.77: DEATH domain [47985] (1 superfamily)
    6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
  76. 1740554a.78: GntR ligand-binding domain-like [48007] (1 superfamily)
    core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
  77. 1740570a.79: NusB-like [48012] (1 superfamily)
    6 helices: bundle; one central helix is surrounded by 5 others
  78. 1740605a.80: post-AAA+ oligomerization domain-like [48018] (1 superfamily)
    core: 5 helices: bundle
  79. 1740698a.81: N-terminal domain of DnaB helicase [48023] (1 superfamily)
    6 helices: array
  80. 1740708a.83: Guanido kinase N-terminal domain [48033] (1 superfamily)
    irregular array of 6 short helices
  81. 1740852a.84: Scaffolding protein gpD of bacteriophage procapsid [48044] (1 superfamily)
    core: 6 helices; one central helix is surrounded by 5 others
  82. 1740866a.85: Hemocyanin, N-terminal domain [48049] (1 superfamily)
    6 helices; bundle; one central helix is surrounded by 5 others
  83. 1740883a.86: Di-copper centre-containing domain [48055] (1 superfamily)
    multihelical
  84. 1740983a.87: DBL homology domain (DH-domain) [48064] (1 superfamily)
    multihelical; core: 5-helical bundle
  85. 1741063a.88: LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1 superfamily)
    multihelical; contains compact array of 6 short helices
  86. 1741072a.89: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1 superfamily)
    multihelical bundle; contains buried central helix
  87. 1741149a.90: Transcription factor STAT-4 N-domain [48091] (1 superfamily)
    multihelical; can be divided into two subdomains
  88. 1741165a.91: Regulator of G-protein signaling, RGS [48096] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
    contains a 4-helical bundle with left-handed twist and up-and-down topology
  89. 1741266a.92: Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
    possible duplication: subdomains have similar topologies
  90. 1741311a.93: Heme-dependent peroxidases [48112] (1 superfamily)
    multihelical; consists of two all-alpha domains
  91. 1742039a.94: Ribosomal protein L19 (L19e) [48139] (1 superfamily)
    multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
  92. 1742102a.95: Influenza virus matrix protein M1 [48144] (1 superfamily)
    multihelical; consists of two different all-alpha subdomains, 4 helices each
  93. 1742126a.96: DNA-glycosylase [48149] (1 superfamily)
    multihelical; consists of two all-alpha domains
  94. 1742282a.97: An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1 superfamily)
    multihelical; consists of two all-alpha domains
  95. 1742323a.98: R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1 superfamily)
    multihelical consists of two all-alpha subdomains
    subdomain 1 (residues 10-100) is a 4-helical bundle
  96. 1742357a.99: Cryptochrome/photolyase FAD-binding domain [48172] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  97. 1742411a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
  98. 1742853a.101: Uteroglobin-like [48200] (1 superfamily)
    multihelical
  99. 1742882a.102: alpha/alpha toroid [48207] (6 superfamilies)
    multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
  100. 1743620a.103: Citrate synthase [48255] (1 superfamily)
    multihelical; consists of two all-alpha domains
  101. 1743740a.104: Cytochrome P450 [48263] (1 superfamily)
    multihelical
  102. 1744811a.108: Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1 superfamily)
    multihelical; intertwined tetramer
  103. 1744855a.109: Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1 superfamily)
    multihelical; intertwined trimer of identical 3-helical subunits
  104. 1744863a.110: Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1 superfamily)
    multihelical; consists of two all-alpha domains
  105. 1744880a.111: Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1 superfamily)
    multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
  106. 1744927a.113: DNA repair protein MutS, domain III [48333] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains
  107. 1744963a.114: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1 superfamily)
    multihelical; bundle of longer and shorter helices
  108. 1744978a.115: A virus capsid protein alpha-helical domain [48344] (1 superfamily)
    multihelical; three-helical bundle in the core is surrounded by non-conserved helices
  109. 1745024a.116: GTPase activation domain, GAP [48349] (1 superfamily)
    multihelical
  110. 1745076a.117: Ras GEF [48365] (1 superfamily)
    multihelical
  111. 1745105a.118: alpha-alpha superhelix [48370] (24 superfamilies)
    multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
  112. 1746708a.119: Lipoxigenase [48483] (1 superfamily)
    multihelical
    large nearly all-alpha domain
  113. 1746761a.120: gene 59 helicase assembly protein [48492] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  114. 1746767a.121: Tetracyclin repressor-like, C-terminal domain [48497] (1 superfamily)
    multihelical; interlocked (homo)dimer
  115. 1747085a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  116. 1748320a.124: Phospholipase C/P1 nuclease [48536] (1 superfamily)
    multihelical
  117. 1748371a.126: Serum albumin-like [48551] (1 superfamily)
    multihelical; one domain consists of two similar disulfide-linked subdomains
  118. 1748834a.127: L-aspartase-like [48556] (1 superfamily)
    multihelical, consists of three all-alpha domains
  119. 1749121a.128: Terpenoid synthases [48575] (1 superfamily)
    multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
  120. 1749675a.129: GroEL equatorial domain-like [48591] (1 superfamily)
    multihelical; 8 helices arranged in 2 parallel layers
  121. 1749889a.130: Chorismate mutase II [48599] (1 superfamily)
    multihelical; core: 6 helices, bundle
  122. 1749959a.131: Peridinin-chlorophyll protein [48607] (1 superfamily)
    multihelical: forms a boat-shaped protein shell around cofactors
  123. 1749970a.132: Heme oxygenase-like [48612] (1 superfamily)
    multihelical; bundle
  124. 1750246a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  125. 1750796a.134: Fungal elicitin [48646] (1 superfamily)
    5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
  126. 1750813a.135: Tetraspanin [48651] (1 superfamily)
    5 helices: irregular disulfide-linked array; form homodimer
  127. 1750844a.136: FinO-like [48656] (1 superfamily)
    6 helices: irregular non-globular array; also contains two small beta-hairpins
  128. 1750858a.137: Non-globular all-alpha subunits of globular proteins [48661] (14 superfamilies)
    not a true fold
  129. 1751105a.138: Multiheme cytochromes [48694] (1 superfamily)
    variable number of helices and little beta structure; not a true fold
  130. 1751406a.139: Type I dockerin domain [63445] (1 superfamily)
    tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
  131. 1751447a.140: LEM/SAP HeH motif [63450] (6 superfamilies)
    helix-extended loop-helix; parallel helices
  132. 1751564a.141: Frizzled cysteine-rich domain [63500] (1 superfamily)
    Core: 3 helices; irregular array; disulfide-rich
  133. 1751593a.142: PTS-regulatory domain, PRD [63519] (1 superfamily)
    core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
  134. 1751602a.143: RPB6/omega subunit-like [63561] (1 superfamily)
    core: 2 helices and adjacent loops
  135. 1751697a.144: PABP domain-like [63569] (2 superfamilies)
    4 helices; an orthogonal array
  136. 1751793a.145: Flagellar transcriptional activator FlhD [63591] (1 superfamily)
    multihelical; forms intertwined dimer of identical 5-helical subunits
  137. 1751808a.146: Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1 superfamily)
    multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
  138. 1751825a.147: Bcr-Abl oncoprotein oligomerization domain [69035] (1 superfamily)
    core: 4 long helices; bundle
  139. 1751838a.148: Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1 superfamily)
    5 helices; one helix is surrounded by the others
  140. 1751862a.149: RNase III domain-like [69064] (1 superfamily)
    core: 5 helices; one helix is surrounded by the others
  141. 1751913a.150: Anti-sigma factor AsiA [69069] (1 superfamily)
    core: 5 helices: orthogonal array
  142. 1751924a.151: Glutamyl tRNA-reductase dimerization domain [69074] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  143. 1751930a.152: AhpD-like [69117] (1 superfamily)
    multihelical; contains 4-helical bundle and 2-helical arm
  144. 1752054a.153: Nuclear receptor coactivator interlocking domain [69124] (1 superfamily)
    3 helices, non-globular array; forms interlocked heterodimers with its targets
  145. 1752075a.154: Variable surface antigen VlsE [74747] (1 superfamily)
    multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
  146. 1752084a.155: H-NS histone-like proteins [81274] (1 superfamily)
    multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
  147. 1752104a.156: S13-like H2TH domain [81297] (1 superfamily)
    core: 3-4 helices
  148. 1752264a.157: Skp1 dimerisation domain-like [81384] (1 superfamily)
    multihelical; interlocked heterodimer with F-box proteins
  149. 1752306a.158: F-box domain [81385] (1 superfamily)
    multihelical; interlocked heterodimer with the Skp1 dimerisation domain
  150. 1752340a.159: Another 3-helical bundle [81602] (5 superfamilies)
    topologically similar to the DNA/RNA-binding bundles; distinct packing
  151. 1752395a.160: PAP/OAS1 substrate-binding domain [81632] (1 superfamily)
    core: 5-helical bundle; up-and-down; right-handed twist
  152. 1752487a.161: beta-catenin-interacting protein ICAT [81729] (1 superfamily)
    core: 3 helices; irregular array
  153. 1752495a.162: Pre-protein crosslinking domain of SecA [81766] (1 superfamily)
    core: 4 helices: bundle; flanked by two short beta-hairpins
    duplication: consists of two structural repeats
  154. 1752512a.163: Crustacean CHH/MIH/GIH neurohormone [81777] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  155. 1752518a.164: C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1 superfamily)
    4 helices; folded leaf; right-handed superhelix
  156. 1752525a.165: Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1 superfamily)
    4 helices; open up-and-down bundle; flexible N-terminal tail
  157. 1752534a.166: RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1 superfamily)
    multihelical; irregular array of long and short helices
  158. 1752560a.168: SopE-like GEF domain [81831] (1 superfamily)
    multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
  159. 1752575a.169: BEACH domain [81836] (1 superfamily)
    multihelical, complex architecture
  160. 1752588a.170: BRCA2 helical domain [81871] (1 superfamily)
    multihelical; contains a 3-helical bundle surrounded by several shorter helices
  161. 1752598a.171: BRCA2 tower domain [81877] (1 superfamily)
    multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
  162. 1752608a.172: Helical scaffold and wing domains of SecA [81885] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains
  163. 1752625a.173: Poly A polymerase C-terminal region-like [81890] (1 superfamily)
    multihelical; can be divided into three subdomains (neck, body and tail)
  164. 1752643a.174: Double Clp-N motif [81922] (1 superfamily)
    multihelical; array
  165. 1752675a.175: Orange carotenoid protein, N-terminal domain [81929] (1 superfamily)
    multihelical; array
  166. 1752692a.176: N-terminal domain of bifunctional PutA protein [81934] (1 superfamily)
    multihelical; array
  167. 1752715a.177: Sigma2 domain of RNA polymerase sigma factors [88945] (1 superfamily)
    multihelical; consists of a conserved 4-helical core and a variable insert subdomain
  168. 1752778a.178: Soluble domain of poliovirus core protein 3a [89042] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  169. 1752785a.179: Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1 superfamily)
    4 helices; bundle, right-handed twist; left-handed superhelix
  170. 1752793a.180: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1 superfamily)
    4 helices; irregular array
  171. 1752800a.181: Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1 superfamily)
    5 helices: orthogonal array
  172. 1752806a.182: GatB/YqeY motif [89094] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
  173. 1752827a.183: Nop domain [89123] (1 superfamily)
    multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
  174. 1752846a.184: TorD-like [89154] (1 superfamily)
    multihelical; bundle
  175. 1752885a.185: Gametocyte protein Pfg27 [89161] (1 superfamily)
    multihelical; bundle
  176. 1752891a.186: KaiA/RbsU domain [101214] (1 superfamily)
    4 helices; bundle, right-handed twist; right-handed superhelix
  177. 1752923a.187: HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1 superfamily)
    4 helices; irregular array
  178. 1752934a.188: PWI domain [101232] (1 superfamily)
    4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
  179. 1752940a.189: XPC-binding domain [101237] (1 superfamily)
    4 helices; array
  180. 1752965a.190: Flavivirus capsid protein C [101256] (1 superfamily)
    core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
  181. 1752981a.191: Methenyltetrahydrofolate cyclohydrolase-like [101261] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  182. 1752988a.192: N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1 superfamily)
    6 helices: bundle; left-handed twist, up-and-down topology
  183. 1752997a.193: GRIP domain [101282] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  184. 1753010a.194: L27 domain [101287] (1 superfamily)
    6 helices, heterodimer of 3-helical domains
  185. 1753047a.195: YutG-like [101306] (1 superfamily)
    core: 6 helices; bundle; one central helix is surrounded by 5 others
  186. 1753065a.196: Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1 superfamily)
    6 helices: orthogonal array
  187. 1753071a.198: YcfC-like [101321] (1 superfamily)
    multihelical; contains two buried central helices
  188. 1753078a.199: YgfB-like [101326] (1 superfamily)
    multihelical; consists of two tightly associated 3-helical bundles with different twists
  189. 1753084a.200: Hypothetical protein MTH393 [101331] (1 superfamily)
    multihelical; consists of two all-alpha subdomains; dimer
  190. 1753091a.202: Superantigen MAM [101343] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  191. 1753106a.203: Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  192. 1753119a.204: all-alpha NTP pyrophosphatases [101385] (1 superfamily)
    multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
  193. 1753229a.205: Hsp90 co-chaperone CDC37 [101390] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains connected by a long helix
  194. 1753235a.206: P40 nucleoprotein [101398] (1 superfamily)
    multihelical; consists of two subdomains
  195. 1753242a.207: Formin homology 2 domain (FH2 domain) [101446] (1 superfamily)
    multihelical, consists of three all-alpha domains
  196. 1753257a.208: DhaL-like [101472] (1 superfamily)
    multihelical; bundle
  197. 1753280a.209: ADP-ribosylglycohydrolase [101477] (1 superfamily)
    multihelical; bundle
  198. 1753301a.210: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1 superfamily)
    5 helices, non-globular array; wraps around the N-terminal tail of its target
  199. 1753307a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  200. 1753939a.212: KRAB domain (Kruppel-associated box) [109639] (1 superfamily)
    2 helices: one short, one long; aromatic-rich iterface
  201. 1753945a.213: DinB/YfiT-like putative metalloenzymes [109853] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
  202. 1753981a.214: NblA-like [109858] (1 superfamily)
    4 helices; dimer of identical alpha-hairpin subunits; open bundle
  203. 1753998a.215: A middle domain of Talin 1 [109879] (1 superfamily)
    5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (47161)
  204. 1754007a.216: I/LWEQ domain [109884] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  205. 1754024a.217: Surp module (SWAP domain) [109904] (1 superfamily)
    5 helices: irregular array
  206. 1754038a.218: YgfY-like [109909] (1 superfamily)
    5 helices; array; forms a tight dimer in crystals
  207. 1754052a.219: Hypothetical protein YhaI [109914] (1 superfamily)
    core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
  208. 1754060a.220: Hypothetical protein At3g22680 [109919] (1 superfamily)
    5 helices; array; probable biological unit is a homodimer
  209. 1754068a.221: Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1 superfamily)
    dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
  210. 1754077a.222: VPS9 domain [109992] (1 superfamily)
    multihelical; consist of two subdomains
  211. 1754086a.223: Triger factor/SurA peptide-binding domain-like [109997] (1 superfamily)
    multihelical; irregular array of long and short helices
  212. 1754112a.224: Glycolipid transfer protein, GLTP [110003] (1 superfamily)
    multihelical; 2 layers or orthogonally packed helices
  213. 1754151a.225: Hypothetical protein MG354 [110008] (1 superfamily)
    multihelical bundle; contains buried central helix
  214. 1754157a.226: Her-1 [110013] (1 superfamily)
    multihelical; consists of two topologically similar alpha-helical bundles
  215. 1754164a.227: ERO1-like [110018] (1 superfamily)
    multihelical; consists of 2 four-helical bundles
  216. 1754174a.228: GDNF receptor-like [110034] (1 superfamily)
    5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (48646)
  217. 1754180a.229: Hypothetical protein YqbG [116914] (1 superfamily)
    core: 4 helices; bundle, right-handed twist; left-handed superhelix
  218. 1754187a.230: YugE-like [116921] (1 superfamily)
    4-helices; bundle; right-handed twist
  219. 1754193a.231: EspA/CesA-like [116926] (1 superfamily)
    4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
  220. 1754203a.232: RNA-binding protein She2p [116941] (1 superfamily)
    5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (48556)
  221. 1754210a.233: YfbU-like [116959] (1 superfamily)
    multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
  222. 1754249a.234: Hypothetical protein MPN330 [116964] (1 superfamily)
    multihelical; consists of three different 4-helical bundles
  223. 1754255a.235: ATP-dependent DNA ligase DNA-binding domain [117017] (1 superfamily)
    multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
  224. 1754261a.236: DNA primase DnaG, C-terminal domain [117022] (1 superfamily)
    multihelical; segment-swapped dimer
  225. 1754275a.237: DNA polymerase III theta subunit-like [116730] (1 superfamily)
    3 helices; irregular array
  226. 1754289a.238: BAR/IMD domain-like [116747] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  227. 1754360a.239: ChaB-like [140375] (1 superfamily)
    3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
  228. 1754366a.240: BSD domain-like [140382] (1 superfamily)
    core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
  229. 1754375a.241: TraM-like [140580] (1 superfamily)
    multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
  230. 1754391a.242: Dcp2 domain-like [140585] (1 superfamily)
    4 helices; orthogonal array of two alpha hairpins
  231. 1754400a.243: Type III secretion system domain [140590] (1 superfamily)
    core: 4 helices, orthogonal array; right-handed superhelix
  232. 1754417a.244: EF2947-like [140606] (1 superfamily)
    4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
  233. 1754423a.245: EB1 dimerisation domain-like [140611] (1 superfamily)
    dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
  234. 1754445a.246: Hyaluronidase domain-like [140656] (3 superfamilies)
    5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
  235. 1754508a.247: YoaC-like [140669] (1 superfamily)
    5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (101214)
  236. 1754517a.248: SP0561-like [140682] (1 superfamily)
    5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
  237. 1754523a.249: YfmB-like [140687] (1 superfamily)
    5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (81593)
  238. 1754530a.250: IpaD-like [140692] (1 superfamily)
    6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
  239. 1754561a.251: Phage replication organizer domain [140712] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  240. 1754578a.252: Mediator hinge subcomplex-like [140717] (1 superfamily)
    6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
  241. 1754594a.253: AF0941-like [140725] (1 superfamily)
    6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
  242. 1754601a.254: PA2201 C-terminal domain-like [140730] (1 superfamily)
    multihelical; seven-helical bundle with buried central helix
  243. 1754609a.255: Rv1873-like [140735] (1 superfamily)
    multihelical; contains unusually short buried central helix
  244. 1754615a.256: RUN domain-like [140740] (1 superfamily)
    multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
  245. 1754625a.257: SipA N-terminal domain-like [140745] (1 superfamily)
    multihelical; bundle; the last helix is buried inside the bundle
  246. 1754632a.258: PG0816-like [140752] (1 superfamily)
    multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (46928)
  247. 1754638a.259: YidB-like [140803] (1 superfamily)
    multihelical; three strings of short helices are packed across one longer helix
  248. 1754644a.260: Rhabdovirus nucleoprotein-like [140808] (1 superfamily)
    multihelical, consist of two helical domains; each domain contains a buried helix
  249. 1754699a.261: GUN4-like [140868] (1 superfamily)
    multihelical; open array, trapping inside an extended region before the C-terminal helix
  250. 1754712a.262: PriB N-terminal domain-like [140913] (1 superfamily)
    multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
  251. 1754719a.263: DNA terminal protein [140918] (1 superfamily)
    multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
  252. 1754730a.264: Duffy binding domain-like [140923] (1 superfamily)
    consist of two subdomains, each containing a three-helical bundle
  253. 1754758a.265: Fic-like [140930] (1 superfamily)
    multihelical; one central helix is surrounded by seven helices
  254. 1754793a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
    multihelical; bundle, contains interrupted helices
  255. 1754876a.267: Topoisomerase V catalytic domain-like [140978] (1 superfamily)
    multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (46688)
  256. 1754885a.268: PTPA-like [140983] (1 superfamily)
    multihelical
  257. 1754915a.269: FtsH protease domain-like [140989] (1 superfamily)
    array of 6 helices and a 2-stranded beta-ribbon
  258. 1754940a.270: Hermes dimerisation domain [140995] (1 superfamily)
    multihelical, intertwinned dimer of two 4-helical strings
  259. 1754947a.271: SOCS box-like [158234] (1 superfamily)
    helix-loop-helix motif with orthogonally packed helices
  260. 1754966a.272: YqgQ-like [158378] (1 superfamily)
    3 helices, bundle, left-handed twist, extended overside connection between the first and second helices
  261. 1754974a.273: Orange domain-like [158456] (1 superfamily)
    4 helices; dimer of identical alpha-hairpin subunits;
  262. 1754983a.274: HAMP domain-like [158471] (1 superfamily)
    dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections
  263. 1755018a.275: DnaD domain-like [158498] (1 superfamily)
    4 helices; bundle, right-handed twist; left-handed superhelix
  264. 1755024a.276: BH2638-like [158503] (1 superfamily)
    4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (81782)
  265. 1755031a.277: TAFH domain-like [158552] (1 superfamily)
    5 helices; folded leaf, closed
  266. 1755042a.278: GINS helical bundle-like [158572] (1 superfamily)
    5 helices, staggered bundle;
  267. 1755088a.279: Jann4075-like [158586] (1 superfamily)
    core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains
  268. 1755097a.280: RbcX-like [158614] (1 superfamily)
    5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer
  269. 1755177a.281: YheA-like [158621] (1 superfamily)
    5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces
  270. 1755203a.282: RPA2825-like [158633] (1 superfamily)
    5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (47089)
  271. 1755209a.283: ENT-like [158638] (1 superfamily)
    5 helices, irregular array, right-handed superhelix
  272. 1755221a.284: YejL-like [158650] (1 superfamily)
    6 helices; intertwined homodimer of three-helical subunits, bundle
  273. 1755247a.285: MtlR-like [158667] (1 superfamily)
    multihelical; 8-helical up-and-down bundle
  274. 1755262a.286: Sama2622-like [158674] (1 superfamily)
    core: 6 helices; bundle; one central helix is surrounded by 5 others
  275. 1755268a.287: TerB-like [158681] (1 superfamily)
    multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry
  276. 1755282a.288: UraD-like [158693] (1 superfamily)
    multihelical; irregular array of long and short helices
  277. 1755310a.289: Sec63 N-terminal domain-like [158701] (1 superfamily)
    multihelical; consists of two helical subdomains
  278. 1755324a.290: PSPTO4464-like [158709] (1 superfamily)
    multihelical; consists of two subdomains at the ends of a long connecting helix
  279. 1755330a.291: MG296-like [158714] (1 superfamily)
    multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix
  280. 1755338a.292: HP0242-like [158751] (1 superfamily)
    multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot
  281. 1755349a.293: SMc04008-like [158756] (1 superfamily)
    multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site
  282. 1755361a.294: Tex N-terminal region-like [158831] (1 superfamily)
    multihelical; irregular array of long and short helices; can be divided into several subdomains
  283. 1755369a.295: AGR_C_984p-like [158836] (1 superfamily)
    multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain
  284. 1755376a.296: PMT central region-like [158841] (1 superfamily)
    multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet
  285. 1755385a.297: DDB1 C-terminal-like [254113] (1 superfamily)
    5 helices in an irregular bundle. Slight similarity to SAM domains (a.60)
  286. 1755393a.298: Left-handed alpha-alpha superhelix [267589] (1 superfamily)
    multihelical; 2 (curved) layers: alpha/alpha; left-handed superhelix

More info for Class a: All alpha proteins

Timeline for Class a: All alpha proteins: