Folds:

1. a.1: Globin-like [46457] (2 superfamilies) core: 6 helices; folded leaf, partly opened

2. a.2: Long alpha-hairpin [46556] (20 superfamilies) 2 helices; antiparallel hairpin, left-handed twist

3. a.3: Cytochrome c [46625] (1 superfamily) core: 3 helices; folded leaf, opened

4. a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies) core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

5. a.5: RuvA C-terminal domain-like [46928] (9 superfamilies) 3 helices; bundle, right-handed twist

6. a.6: Putative DNA-binding domain [46954] (1 superfamily) core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different

7. a.7: Spectrin repeat-like [46965] (16 superfamilies) 3 helices; bundle, closed, left-handed twist; up-and-down

8. a.8: immunoglobulin/albumin-binding domain-like [46996] (11 superfamilies) 3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold

9. a.9: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1 superfamily) 3 helices; bundle, closed, right-handed twist; up-and-down

10. a.10: Protozoan pheromone-like [47013] (2 superfamilies) 3 helices; bundle, closed, left-handed twist, up-and-down

11. a.11: Acyl-CoA binding protein-like [47026] (2 superfamilies) core: 3 helices; bundle, closed, left-handed twist; up-and-down

12. a.12: Kix domain of CBP (creb binding protein) [47039] (1 superfamily) 3 helices; bundle, partly opened

13. a.13: RAP domain-like [47044] (1 superfamily) 3 helices, the first one is shorter than the other two; bundle, partly opened

14. a.14: VHP, Villin headpiece domain [47049] (1 superfamily) 3 short helices; irregular array

15. a.15: TAF(II)230 TBP-binding fragment [47054] (1 superfamily) 3 short helices; irregular array

16. a.16: S15/NS1 RNA-binding domain [47059] (1 superfamily) 3 helices; irregular array

17. a.17: Cysteine alpha-hairpin motif [47071] (1 superfamily) core: alpha-hairpin crosslinked with two disulfides

18. a.18: T4 endonuclease V [47076] (1 superfamily) 3 helices; irregular array

19. a.19: Fertilization protein [47081] (1 superfamily) core: 3 helices; bundle, closed, right-handed twist; up-and-down

20. a.20: PGBD-like [47089] (1 superfamily) core: 3 helices; bundle, closed, left-handed twist; parallel

21. a.21: HMG-box [47094] (1 superfamily) 3 helices; irregular array

22. a.22: Histone-fold [47112] (1 superfamily) core: 3 helices; long middle helix is flanked at each end with shorter ones

23. a.23: Open three-helical up-and-down bundle [47143] (7 superfamilies) core: 3 helices; bundle, open

24. a.24: Four-helical up-and-down bundle [47161] (28 superfamilies) core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

25. a.25: Ferritin-like [47239] (6 superfamilies) core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection

26. a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

27. a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily) core: 4 helices; bundle; one loop crosses over one side of the bundle

28. a.28: Acyl carrier protein-like [47335] (3 superfamilies) 4 helices, bundle; helix 3 is shorter than others; up-and-down

29. a.29: Bromodomain-like [47363] (15 superfamilies) 4 helices; bundle; minor mirror variant of up-and-down topology

30. a.30: ROP-like [47379] (8 superfamilies) 4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist

31. a.31: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1 superfamily) 4 helices; bundle, closed, right-handed twist

32. a.32: Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1 superfamily) 4 helices; bundle, closed, right-handed twist

33. a.33: Ectatomin subunits [47400] (1 superfamily) 4 helices; bundle, closed, left-handed twist

34. a.34: Dimerisation interlock [47405] (4 superfamilies) 4 helices; bundle, closed, right-handed twist

35. a.35: lambda repressor-like DNA-binding domains [47412] (1 superfamily) core: 4 helices; folded leaf, closed

36. a.36: Signal peptide-binding domain [47445] (1 superfamily) 4 helices; orthogonal array

37. a.37: A DNA-binding domain in eukaryotic transcription factors [47453] (1 superfamily) 4 helices; the long C-terminal helix protrudes from the domain and binds to DNA

38. a.38: HLH-like [47458] (2 superfamilies) 4-helices; bundle, closed, left-handed twist; 2 crossover connections

39. a.39: EF Hand-like [47472] (4 superfamilies) core: 4 helices; array of 2 hairpins, opened

40. a.40: CH domain-like [47575] (3 superfamilies) core: 4 helices: bundle

41. a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily) core: 4 helices: bundle; unusual topology

42. a.42: SWIB/MDM2 domain [47591] (1 superfamily) core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets duplication: consists of two structural repeats

43. a.43: Ribbon-helix-helix [47597] (1 superfamily) core: 4 helices; array of 2 hairpins, opened

44. a.45: GST C-terminal domain-like [47615] (1 superfamily) core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix

45. a.46: Methionine synthase domain-like [47643] (3 superfamilies) 4 helices; bundle, left-handed twist; right-handed superhelix

46. a.47: STAT-like [47654] (6 superfamilies) 4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix

47. a.48: N-cbl like [47667] (5 superfamilies) 4 helices; bundle, left-handed twist; left-handed superhelix

48. a.49: C-terminal domain of B transposition protein [47680] (1 superfamily) 4 helices; irregular array

49. a.50: Anaphylotoxins (complement system) [47685] (1 superfamily) 4 helices; irregular array, disulfide-linked

50. a.51: Cytochrome c oxidase subunit h [47693] (1 superfamily) 4 helices; irregular array, disulfide-linked

51. a.52: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1 superfamily) 4 helices; folded leaf; right-handed superhelix

52. a.53: p53 tetramerization domain [47718] (1 superfamily) core: 4 helices; bundle

53. a.54: Domain of early E2A DNA-binding protein, ADDBP [47723] (1 superfamily) 4 helices; bundle, partly opened

54. a.55: IHF-like DNA-binding proteins [47728] (1 superfamily) core: 4 helices; bundle, partly opened, capped with a beta-sheet

55. a.56: CO dehydrogenase ISP C-domain like [47740] (1 superfamily) core: 4 helices, bundle

56. a.57: Protein HNS-dependent expression A; HdeA [47751] (1 superfamily) 4 helices; the three last helices form a bundle similar to that of the RuvA C-domain

57. a.58: Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1 superfamily) 4 helices; an orthogonal array

58. a.59: PAH2 domain [47761] (1 superfamily) 4 helices; open up-and-down bundle; binds alpha-helical peptides

59. a.60: SAM domain-like [47768] (16 superfamilies) 4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

60. a.61: Retroviral matrix proteins [47835] (1 superfamily) 4-5 helices; right-handed superhelix

61. a.62: Hepatitis B viral capsid (hbcag) [47851] (1 superfamily) 5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle

62. a.63: Apolipophorin-III [47856] (1 superfamily) 5 helices; bundle, closed, left-handed twist

63. a.64: Saposin-like [47861] (2 superfamilies) 5 helices; folded leaf, closed

64. a.65: Annexin [47873] (1 superfamily) 5 helices; folded leaf, closed

65. a.66: Transducin (alpha subunit), insertion domain [47894] (1 superfamily) 5 helices; folded leaf

66. a.68: Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1 superfamily) 5 helices; irregular array; left-handed superhelix

67. a.69: Left-handed superhelix [47916] (4 superfamilies) core: 4-5 helices; bundle; left-handed superhelix

68. a.70: ATPD N-terminal domain-like [47927] (2 superfamilies) core: 5 helices; bundle

69. a.71: ERP29 C domain-like [47932] (2 superfamilies) 5 helices; bundle

70. a.72: Functional domain of the splicing factor Prp18 [47937] (1 superfamily) core: 5 helices; bundle

71. a.73: Retrovirus capsid protein, N-terminal core domain [47942] (1 superfamily) core: 5 helices; bundle

72. a.74: Cyclin-like [47953] (1 superfamily) core: 5 helices; one helix is surrounded by the others

73. a.75: Ribosomal protein S7 [47972] (1 superfamily) core: 5 helices; contains one more helix and a beta-hairpin outside the core

74. a.76: Iron-dependent repressor protein, dimerization domain [47978] (1 superfamily) 6 helices, homodimer of 3-helical domains

75. a.77: DEATH domain [47985] (1 superfamily) 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

76. a.78: GntR ligand-binding domain-like [48007] (1 superfamily) core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

77. a.79: NusB-like [48012] (1 superfamily) 6 helices: bundle; one central helix is surrounded by 5 others

78. a.80: post-AAA+ oligomerization domain-like [48018] (1 superfamily) core: 5 helices: bundle

79. a.81: N-terminal domain of DnaB helicase [48023] (1 superfamily) 6 helices: array

80. a.83: Guanido kinase N-terminal domain [48033] (1 superfamily) irregular array of 6 short helices

81. a.84: Scaffolding protein gpD of bacteriophage procapsid [48044] (1 superfamily) core: 6 helices; one central helix is surrounded by 5 others

82. a.85: Hemocyanin, N-terminal domain [48049] (1 superfamily) 6 helices; bundle; one central helix is surrounded by 5 others

83. a.86: Di-copper centre-containing domain [48055] (1 superfamily) multihelical

84. a.87: DBL homology domain (DH-domain) [48064] (1 superfamily) multihelical; core: 5-helical bundle

85. a.88: LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1 superfamily) multihelical; contains compact array of 6 short helices

86. a.89: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1 superfamily) multihelical bundle; contains buried central helix

87. a.90: Transcription factor STAT-4 N-domain [48091] (1 superfamily) multihelical; can be divided into two subdomains

88. a.91: Regulator of G-protein signaling, RGS [48096] (1 superfamily) multihelical; consists of two all-alpha subdomains contains a 4-helical bundle with left-handed twist and up-and-down topology

89. a.92: Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1 superfamily) multihelical; consists of two all-alpha subdomains possible duplication: subdomains have similar topologies

90. a.93: Heme-dependent peroxidases [48112] (1 superfamily) multihelical; consists of two all-alpha domains

91. a.94: Ribosomal protein L19 (L19e) [48139] (1 superfamily) multihelical; consists of two different 3-helical domains connected by a long, partly helical linker

92. a.95: Influenza virus matrix protein M1 [48144] (1 superfamily) multihelical; consists of two different all-alpha subdomains, 4 helices each

93. a.96: DNA-glycosylase [48149] (1 superfamily) multihelical; consists of two all-alpha domains

94. a.97: An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1 superfamily) multihelical; consists of two all-alpha domains

95. a.98: R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1 superfamily) multihelical consists of two all-alpha subdomains subdomain 1 (residues 10-100) is a 4-helical bundle

96. a.99: Cryptochrome/photolyase FAD-binding domain [48172] (1 superfamily) multihelical; consists of two all-alpha subdomains

97. a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily) multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

98. a.101: Uteroglobin-like [48200] (1 superfamily) multihelical

99. a.102: alpha/alpha toroid [48207] (6 superfamilies) multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

100. a.103: Citrate synthase [48255] (1 superfamily) multihelical; consists of two all-alpha domains

101. a.104: Cytochrome P450 [48263] (1 superfamily) multihelical

102. a.108: Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1 superfamily) multihelical; intertwined tetramer

103. a.109: Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1 superfamily) multihelical; intertwined trimer of identical 3-helical subunits

104. a.110: Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1 superfamily) multihelical; consists of two all-alpha domains

105. a.111: Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1 superfamily) multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix

106. a.113: DNA repair protein MutS, domain III [48333] (1 superfamily) multihelical; consists of 2 all-alpha subdomains

107. a.114: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1 superfamily) multihelical; bundle of longer and shorter helices

108. a.115: A virus capsid protein alpha-helical domain [48344] (1 superfamily) multihelical; three-helical bundle in the core is surrounded by non-conserved helices

109. a.116: GTPase activation domain, GAP [48349] (1 superfamily) multihelical

110. a.117: Ras GEF [48365] (1 superfamily) multihelical

111. a.118: alpha-alpha superhelix [48370] (24 superfamilies) multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

112. a.119: Lipoxigenase [48483] (1 superfamily) multihelical large nearly all-alpha domain

113. a.120: gene 59 helicase assembly protein [48492] (1 superfamily) multihelical; consists of two all-alpha subdomains

114. a.121: Tetracyclin repressor-like, C-terminal domain [48497] (1 superfamily) multihelical; interlocked (homo)dimer

115. a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily) multihelical; 3 layers or orthogonally packed helices

116. a.124: Phospholipase C/P1 nuclease [48536] (1 superfamily) multihelical

117. a.126: Serum albumin-like [48551] (1 superfamily) multihelical; one domain consists of two similar disulfide-linked subdomains

118. a.127: L-aspartase-like [48556] (1 superfamily) multihelical, consists of three all-alpha domains

119. a.128: Terpenoid synthases [48575] (1 superfamily) multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

120. a.129: GroEL equatorial domain-like [48591] (1 superfamily) multihelical; 8 helices arranged in 2 parallel layers

121. a.130: Chorismate mutase II [48599] (1 superfamily) multihelical; core: 6 helices, bundle

122. a.131: Peridinin-chlorophyll protein [48607] (1 superfamily) multihelical: forms a boat-shaped protein shell around cofactors

123. a.132: Heme oxygenase-like [48612] (1 superfamily) multihelical; bundle

124. a.133: Phospholipase A2, PLA2 [48618] (1 superfamily) common core: 2 helices, disulfide-linked, and a calcium-binding loop

125. a.134: Fungal elicitin [48646] (1 superfamily) 5 helices: irregular disulfide-linked array; also contains a small beta-hairpin

126. a.135: Tetraspanin [48651] (1 superfamily) 5 helices: irregular disulfide-linked array; form homodimer

127. a.136: FinO-like [48656] (1 superfamily) 6 helices: irregular non-globular array; also contains two small beta-hairpins

128. a.137: Non-globular all-alpha subunits of globular proteins [48661] (14 superfamilies) not a true fold

129. a.138: Multiheme cytochromes [48694] (1 superfamily) variable number of helices and little beta structure; not a true fold

130. a.139: Type I dockerin domain [63445] (1 superfamily) tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand

131. a.140: LEM/SAP HeH motif [63450] (6 superfamilies) helix-extended loop-helix; parallel helices

132. a.141: Frizzled cysteine-rich domain [63500] (1 superfamily) Core: 3 helices; irregular array; disulfide-rich

133. a.142: PTS-regulatory domain, PRD [63519] (1 superfamily) core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection

134. a.143: RPB6/omega subunit-like [63561] (1 superfamily) core: 2 helices and adjacent loops

135. a.144: PABP domain-like [63569] (2 superfamilies) 4 helices; an orthogonal array

136. a.145: Flagellar transcriptional activator FlhD [63591] (1 superfamily) multihelical; forms intertwined dimer of identical 5-helical subunits

137. a.146: Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1 superfamily) multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain

138. a.147: Bcr-Abl oncoprotein oligomerization domain [69035] (1 superfamily) core: 4 long helices; bundle

139. a.148: Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1 superfamily) 5 helices; one helix is surrounded by the others

140. a.149: RNase III domain-like [69064] (1 superfamily) core: 5 helices; one helix is surrounded by the others

141. a.150: Anti-sigma factor AsiA [69069] (1 superfamily) core: 5 helices: orthogonal array

142. a.151: Glutamyl tRNA-reductase dimerization domain [69074] (1 superfamily) 6 helices, homodimer of 3-helical domains

143. a.152: AhpD-like [69117] (1 superfamily) multihelical; contains 4-helical bundle and 2-helical arm

144. a.153: Nuclear receptor coactivator interlocking domain [69124] (1 superfamily) 3 helices, non-globular array; forms interlocked heterodimers with its targets

145. a.154: Variable surface antigen VlsE [74747] (1 superfamily) multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology

146. a.155: H-NS histone-like proteins [81274] (1 superfamily) multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains

147. a.156: S13-like H2TH domain [81297] (1 superfamily) core: 3-4 helices

148. a.157: Skp1 dimerisation domain-like [81384] (1 superfamily) multihelical; interlocked heterodimer with F-box proteins

149. a.158: F-box domain [81385] (1 superfamily) multihelical; interlocked heterodimer with the Skp1 dimerisation domain

150. a.159: Another 3-helical bundle [81602] (5 superfamilies) topologically similar to the DNA/RNA-binding bundles; distinct packing

151. a.160: PAP/OAS1 substrate-binding domain [81632] (1 superfamily) core: 5-helical bundle; up-and-down; right-handed twist

152. a.161: beta-catenin-interacting protein ICAT [81729] (1 superfamily) core: 3 helices; irregular array

153. a.162: Pre-protein crosslinking domain of SecA [81766] (1 superfamily) core: 4 helices: bundle; flanked by two short beta-hairpins duplication: consists of two structural repeats

154. a.163: Crustacean CHH/MIH/GIH neurohormone [81777] (1 superfamily) 4 helices; irregular array, disulfide-linked

155. a.164: C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1 superfamily) 4 helices; folded leaf; right-handed superhelix

156. a.165: Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1 superfamily) 4 helices; open up-and-down bundle; flexible N-terminal tail

157. a.166: RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1 superfamily) multihelical; irregular array of long and short helices

158. a.168: SopE-like GEF domain [81831] (1 superfamily) multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist

159. a.169: BEACH domain [81836] (1 superfamily) multihelical, complex architecture

160. a.170: BRCA2 helical domain [81871] (1 superfamily) multihelical; contains a 3-helical bundle surrounded by several shorter helices

161. a.171: BRCA2 tower domain [81877] (1 superfamily) multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices

162. a.172: Helical scaffold and wing domains of SecA [81885] (1 superfamily) multihelical; consists of 2 all-alpha subdomains

163. a.173: Poly A polymerase C-terminal region-like [81890] (1 superfamily) multihelical; can be divided into three subdomains (neck, body and tail)

164. a.174: Double Clp-N motif [81922] (1 superfamily) multihelical; array

165. a.175: Orange carotenoid protein, N-terminal domain [81929] (1 superfamily) multihelical; array

166. a.176: N-terminal domain of bifunctional PutA protein [81934] (1 superfamily) multihelical; array

167. a.177: Sigma2 domain of RNA polymerase sigma factors [88945] (1 superfamily) multihelical; consists of a conserved 4-helical core and a variable insert subdomain

168. a.178: Soluble domain of poliovirus core protein 3a [89042] (1 superfamily) 4 helices; bundle, closed, right-handed twist

169. a.179: Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1 superfamily) 4 helices; bundle, right-handed twist; left-handed superhelix

170. a.180: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1 superfamily) 4 helices; irregular array

171. a.181: Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1 superfamily) 5 helices: orthogonal array

172. a.182: GatB/YqeY motif [89094] (1 superfamily) multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)

173. a.183: Nop domain [89123] (1 superfamily) multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain

174. a.184: TorD-like [89154] (1 superfamily) multihelical; bundle

175. a.185: Gametocyte protein Pfg27 [89161] (1 superfamily) multihelical; bundle

176. a.186: KaiA/RbsU domain [101214] (1 superfamily) 4 helices; bundle, right-handed twist; right-handed superhelix

177. a.187: HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1 superfamily) 4 helices; irregular array

178. a.188: PWI domain [101232] (1 superfamily) 4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds

179. a.189: XPC-binding domain [101237] (1 superfamily) 4 helices; array

180. a.190: Flavivirus capsid protein C [101256] (1 superfamily) core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices

181. a.191: Methenyltetrahydrofolate cyclohydrolase-like [101261] (1 superfamily) 5 helices; bundle, closed, left-handed twist

182. a.192: N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1 superfamily) 6 helices: bundle; left-handed twist, up-and-down topology

183. a.193: GRIP domain [101282] (1 superfamily) 6 helices, homodimer of 3-helical domains

184. a.194: L27 domain [101287] (1 superfamily) 6 helices, heterodimer of 3-helical domains

185. a.195: YutG-like [101306] (1 superfamily) core: 6 helices; bundle; one central helix is surrounded by 5 others

186. a.196: Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1 superfamily) 6 helices: orthogonal array

187. a.198: YcfC-like [101321] (1 superfamily) multihelical; contains two buried central helices

188. a.199: YgfB-like [101326] (1 superfamily) multihelical; consists of two tightly associated 3-helical bundles with different twists

189. a.200: Hypothetical protein MTH393 [101331] (1 superfamily) multihelical; consists of two all-alpha subdomains; dimer

190. a.202: Superantigen MAM [101343] (1 superfamily) multihelical; consists of two different alpha-helical bundles

191. a.203: Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1 superfamily) multihelical; consists of two all-alpha subdomains

192. a.204: all-alpha NTP pyrophosphatases [101385] (1 superfamily) multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer

193. a.205: Hsp90 co-chaperone CDC37 [101390] (1 superfamily) multihelical; consists of 2 all-alpha subdomains connected by a long helix

194. a.206: P40 nucleoprotein [101398] (1 superfamily) multihelical; consists of two subdomains

195. a.207: Formin homology 2 domain (FH2 domain) [101446] (1 superfamily) multihelical, consists of three all-alpha domains

196. a.208: DhaL-like [101472] (1 superfamily) multihelical; bundle

197. a.209: ADP-ribosylglycohydrolase [101477] (1 superfamily) multihelical; bundle

198. a.210: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1 superfamily) 5 helices, non-globular array; wraps around the N-terminal tail of its target

199. a.211: HD-domain/PDEase-like [109603] (1 superfamily) multihelical; consists of two different alpha-helical bundles

200. a.212: KRAB domain (Kruppel-associated box) [109639] (1 superfamily) 2 helices: one short, one long; aromatic-rich iterface

201. a.213: DinB/YfiT-like putative metalloenzymes [109853] (1 superfamily) core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order

202. a.214: NblA-like [109858] (1 superfamily) 4 helices; dimer of identical alpha-hairpin subunits; open bundle

203. a.215: A middle domain of Talin 1 [109879] (1 superfamily) 5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (47161)

204. a.216: I/LWEQ domain [109884] (1 superfamily) 5 helices; bundle, closed, left-handed twist

205. a.217: Surp module (SWAP domain) [109904] (1 superfamily) 5 helices: irregular array

206. a.218: YgfY-like [109909] (1 superfamily) 5 helices; array; forms a tight dimer in crystals

207. a.219: Hypothetical protein YhaI [109914] (1 superfamily) core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)

208. a.220: Hypothetical protein At3g22680 [109919] (1 superfamily) 5 helices; array; probable biological unit is a homodimer

209. a.221: Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1 superfamily) dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil

210. a.222: VPS9 domain [109992] (1 superfamily) multihelical; consist of two subdomains

211. a.223: Triger factor/SurA peptide-binding domain-like [109997] (1 superfamily) multihelical; irregular array of long and short helices

212. a.224: Glycolipid transfer protein, GLTP [110003] (1 superfamily) multihelical; 2 layers or orthogonally packed helices

213. a.225: Hypothetical protein MG354 [110008] (1 superfamily) multihelical bundle; contains buried central helix

214. a.226: Her-1 [110013] (1 superfamily) multihelical; consists of two topologically similar alpha-helical bundles

215. a.227: ERO1-like [110018] (1 superfamily) multihelical; consists of 2 four-helical bundles

216. a.228: GDNF receptor-like [110034] (1 superfamily) 5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (48646)

217. a.229: Hypothetical protein YqbG [116914] (1 superfamily) core: 4 helices; bundle, right-handed twist; left-handed superhelix

218. a.230: YugE-like [116921] (1 superfamily) 4-helices; bundle; right-handed twist

219. a.231: EspA/CesA-like [116926] (1 superfamily) 4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits

220. a.232: RNA-binding protein She2p [116941] (1 superfamily) 5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (48556)

221. a.233: YfbU-like [116959] (1 superfamily) multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes

222. a.234: Hypothetical protein MPN330 [116964] (1 superfamily) multihelical; consists of three different 4-helical bundles

223. a.235: ATP-dependent DNA ligase DNA-binding domain [117017] (1 superfamily) multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry

224. a.236: DNA primase DnaG, C-terminal domain [117022] (1 superfamily) multihelical; segment-swapped dimer

225. a.237: DNA polymerase III theta subunit-like [116730] (1 superfamily) 3 helices; irregular array

226. a.238: BAR/IMD domain-like [116747] (1 superfamily) 6 helices, homodimer of 3-helical domains

227. a.239: ChaB-like [140375] (1 superfamily) 3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin

228. a.240: BSD domain-like [140382] (1 superfamily) core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure

229. a.241: TraM-like [140580] (1 superfamily) multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices

230. a.242: Dcp2 domain-like [140585] (1 superfamily) 4 helices; orthogonal array of two alpha hairpins

231. a.243: Type III secretion system domain [140590] (1 superfamily) core: 4 helices, orthogonal array; right-handed superhelix

232. a.244: EF2947-like [140606] (1 superfamily) 4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad

233. a.245: EB1 dimerisation domain-like [140611] (1 superfamily) dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices

234. a.246: Hyaluronidase domain-like [140656] (3 superfamilies) 5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology

235. a.247: YoaC-like [140669] (1 superfamily) 5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (101214)

236. a.248: SP0561-like [140682] (1 superfamily) 5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder

237. a.249: YfmB-like [140687] (1 superfamily) 5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (81593)

238. a.250: IpaD-like [140692] (1 superfamily) 6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest

239. a.251: Phage replication organizer domain [140712] (1 superfamily) 6 helices, homodimer of 3-helical domains

240. a.252: Mediator hinge subcomplex-like [140717] (1 superfamily) 6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure

241. a.253: AF0941-like [140725] (1 superfamily) 6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix

242. a.254: PA2201 C-terminal domain-like [140730] (1 superfamily) multihelical; seven-helical bundle with buried central helix

243. a.255: Rv1873-like [140735] (1 superfamily) multihelical; contains unusually short buried central helix

244. a.256: RUN domain-like [140740] (1 superfamily) multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other

245. a.257: SipA N-terminal domain-like [140745] (1 superfamily) multihelical; bundle; the last helix is buried inside the bundle

246. a.258: PG0816-like [140752] (1 superfamily) multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (46928)

247. a.259: YidB-like [140803] (1 superfamily) multihelical; three strings of short helices are packed across one longer helix

248. a.260: Rhabdovirus nucleoprotein-like [140808] (1 superfamily) multihelical, consist of two helical domains; each domain contains a buried helix

249. a.261: GUN4-like [140868] (1 superfamily) multihelical; open array, trapping inside an extended region before the C-terminal helix

250. a.262: PriB N-terminal domain-like [140913] (1 superfamily) multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)

251. a.263: DNA terminal protein [140918] (1 superfamily) multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix

252. a.264: Duffy binding domain-like [140923] (1 superfamily) consist of two subdomains, each containing a three-helical bundle

253. a.265: Fic-like [140930] (1 superfamily) multihelical; one central helix is surrounded by seven helices

254. a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily) multihelical; bundle, contains interrupted helices

255. a.267: Topoisomerase V catalytic domain-like [140978] (1 superfamily) multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (46688)

256. a.268: PTPA-like [140983] (1 superfamily) multihelical

257. a.269: FtsH protease domain-like [140989] (1 superfamily) array of 6 helices and a 2-stranded beta-ribbon

258. a.270: Hermes dimerisation domain [140995] (1 superfamily) multihelical, intertwinned dimer of two 4-helical strings

259. a.271: SOCS box-like [158234] (1 superfamily) helix-loop-helix motif with orthogonally packed helices

260. a.272: YqgQ-like [158378] (1 superfamily) 3 helices, bundle, left-handed twist, extended overside connection between the first and second helices

261. a.273: Orange domain-like [158456] (1 superfamily) 4 helices; dimer of identical alpha-hairpin subunits;

262. a.274: HAMP domain-like [158471] (1 superfamily) dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections

263. a.275: DnaD domain-like [158498] (1 superfamily) 4 helices; bundle, right-handed twist; left-handed superhelix

264. a.276: BH2638-like [158503] (1 superfamily) 4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (81782)

265. a.277: TAFH domain-like [158552] (1 superfamily) 5 helices; folded leaf, closed

266. a.278: GINS helical bundle-like [158572] (1 superfamily) 5 helices, staggered bundle;

267. a.279: Jann4075-like [158586] (1 superfamily) core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains

268. a.280: RbcX-like [158614] (1 superfamily) 5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer

269. a.281: YheA-like [158621] (1 superfamily) 5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces

270. a.282: RPA2825-like [158633] (1 superfamily) 5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (47089)

271. a.283: ENT-like [158638] (1 superfamily) 5 helices, irregular array, right-handed superhelix

272. a.284: YejL-like [158650] (1 superfamily) 6 helices; intertwined homodimer of three-helical subunits, bundle

273. a.285: MtlR-like [158667] (1 superfamily) multihelical; 8-helical up-and-down bundle

274. a.286: Sama2622-like [158674] (1 superfamily) core: 6 helices; bundle; one central helix is surrounded by 5 others

275. a.287: TerB-like [158681] (1 superfamily) multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry

276. a.288: UraD-like [158693] (1 superfamily) multihelical; irregular array of long and short helices

277. a.289: Sec63 N-terminal domain-like [158701] (1 superfamily) multihelical; consists of two helical subdomains

278. a.290: PSPTO4464-like [158709] (1 superfamily) multihelical; consists of two subdomains at the ends of a long connecting helix

279. a.291: MG296-like [158714] (1 superfamily) multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix

280. a.292: HP0242-like [158751] (1 superfamily) multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot

281. a.293: SMc04008-like [158756] (1 superfamily) multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site

282. a.294: Tex N-terminal region-like [158831] (1 superfamily) multihelical; irregular array of long and short helices; can be divided into several subdomains

283. a.295: AGR_C_984p-like [158836] (1 superfamily) multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain

284. a.296: PMT central region-like [158841] (1 superfamily) multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet

285. a.297: DDB1 C-terminal-like [254113] (1 superfamily) 5 helices in an irregular bundle. Slight similarity to SAM domains (a.60)

286. a.298: Left-handed alpha-alpha superhelix [267589] (1 superfamily) multihelical; 2 (curved) layers: alpha/alpha; left-handed superhelix

More info for Class a: All alpha proteins

Timeline for Class a: All alpha proteins:

• Class a: All alpha proteins first appeared (with stable ids) in SCOP 1.55
  
• Class a: All alpha proteins appears in SCOPe 2.04
  
• Class a: All alpha proteins appears in SCOPe 2.06
  
• Class a: All alpha proteins appears in the current release, SCOPe 2.08