SCOPe 2.07: Domain d4iwda1: 4iwd A:1048-1348

Lineage for d4iwda1 (4iwd A:1048-1348)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (58 PDB entries)

8. Domain d4iwda1: 4iwd A:1048-1348 [229626]
   Other proteins in same PDB: d4iwda2, d4iwda3
   automated match to d3r7oa_
   complexed with 1jc

Details for d4iwda1

PDB Entry: 4iwd, 1.99 Å

PDB Description: structure of dually phosphorylated c-met receptor kinase in complex with an mk-8033 analog

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d4iwda1:

Sequence, based on SEQRES records:

>d4iwda1 d.144.1.7 (A:1048-1348) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdv
ntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfige
h

Sequence, based on observed residues (ATOM records):

>d4iwda1 d.144.1.7 (A:1048-1348) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfd
itvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigeh

Timeline for d4iwda1:

• d4iwda1 first appeared in SCOPe 2.03, called d4iwda_
  
• d4iwda1 appears in SCOPe 2.06
  
• d4iwda1 appears in the current release, SCOPe 2.08