SCOPe 2.04: Domain d4i5xa_: 4i5x A:

Lineage for d4i5xa_ (4i5x A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (102 PDB entries)
   Uniprot P15121

8. Domain d4i5xa_: 4i5x A: [228451]
   automated match to d4gqga_
   complexed with flf, nap

Details for d4i5xa_

PDB Entry: 4i5x, 2.1 Å

PDB Description: Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid

PDB Compounds: (A:) Aldo-keto reductase family 1 member B10

SCOPe Domain Sequences for d4i5xa_:

Sequence; same for both SEQRES and ATOM records:

>d4i5xa_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
ahmatfvelstkakmpivglgtwksplgkvkeavkvaidagyrhidcayvyqnehevgea
iqekiqekavkredlfivsklwptfferplvrkafektlkdlklsyldvylihwpqgfks
gddlfpkddkgnaiggkatfldaweameelvdeglvkalgvsnfshfqiekllnkpglky
kpvtnqvechpyltqekliqychskgitvtaysplgspdrpwakpedpslledpkikeia
akhkktaaqvlirfhiqrnvivipksvtpariveniqvfdfklsdeematilsfnrnwra
cnvlqsshledypfdaey

Timeline for d4i5xa_:

• d4i5xa_ first appeared in SCOPe 2.03
  
• d4i5xa_ appears in SCOPe 2.05
  
• d4i5xa_ appears in the current release, SCOPe 2.08, called d4i5xa1