SCOPe 2.04: Domain d4kaka_: 4kak A:

Lineage for d4kaka_ (4kak A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d4kaka_: 4kak A: [228206]
   automated match to d1kmva_
   complexed with 06u, ca, eoh, ndp

Details for d4kaka_

PDB Entry: 4kak, 1.8 Å

PDB Description: Crystal structure of human dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3S)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4kaka_:

Sequence; same for both SEQRES and ATOM records:

>d4kaka_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d4kaka_:

• d4kaka_ first appeared in SCOPe 2.03
  
• d4kaka_ appears in SCOPe 2.05
  
• d4kaka_ appears in the current release, SCOPe 2.08