Lineage for d4kaka_ (4kak A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137109Domain d4kaka_: 4kak A: [228206]
    automated match to d1kmva_
    complexed with 06u, ca, eoh, ndp

Details for d4kaka_

PDB Entry: 4kak (more details), 1.8 Å

PDB Description: Crystal structure of human dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3S)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4kaka_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4kaka_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4kaka_:

Click to download the PDB-style file with coordinates for d4kaka_.
(The format of our PDB-style files is described here.)

Timeline for d4kaka_: