SCOPe 2.05: Domain d4kaoa_: 4kao A:

Lineage for d4kaoa_ (4kao A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)

8. Domain d4kaoa_: 4kao A: [227894]
   automated match to d3pxka_
   complexed with kao, so4

Details for d4kaoa_

PDB Entry: 4kao, 2.39 Å

PDB Description: focal adhesion kinase catalytic domain in complex with 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea

PDB Compounds: (A:) Focal adhesion kinase 1

SCOPe Domain Sequences for d4kaoa_:

Sequence, based on SEQRES records:

>d4kaoa_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapesi
nfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlysl
mtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d4kaoa_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspalavaiktcknctsdsvrekflqealtmrq
fdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstalayl
eskrfvhrdiaarnvlvssndcvklgdfglpikwmapesinfrrftsasdvwmfgvcmwe
ilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprftelka
qlstileeekaq

Timeline for d4kaoa_:

• d4kaoa_ first appeared in SCOPe 2.03
  
• d4kaoa_ appears in SCOPe 2.04
  
• d4kaoa_ appears in SCOPe 2.06
  
• d4kaoa_ appears in the current release, SCOPe 2.08